|
| Article Authors: | R Wang; D L Doolan; T P Le; R C Hedstrom; K M Coonan; Y Charoenvit; T R Jones; P Hobart; M Margalith; J Ng; W R Weiss; M Sedegah; C de Taisne; J A Norman; S L Hoffman |
|---|
| Article Title: | Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. |
|---|
|
| Reference ID: | 1002777 |
|---|
| Abstract: | CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8+ T cell responses. Malaria-naïve volunteers who were vaccinated with plasmid DNA encoding a malaria protein developed antigen-specific, genetically restricted, CD8+ T cell-dependent CTLs. Responses were directed against all 10 peptides tested and were restricted by six human lymphocyte antigen (HLA) class I alleles. This first demonstration in healthy naïve humans of the induction of CD8+ CTLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology. |
|---|
| Affiliations: | Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889-5607, USA. |
|---|
| Date: | 1998 |
|---|
| Reference Type: | Literature |
|---|
| PubMed ID: | 9774275 |
|---|
| Journal: | Science |
|---|
| Journal Volume: | 282 |
|---|
| Article Pages: | 476-80 |
|---|
| Journal ISSN: | 1095-9203 |
|---|
| Article Chemical List: | Antigens, Protozoan;HLA Antigens;Malaria Vaccines;Protozoan Proteins;Vaccines, DNA;circumsporozoite protein, Protozoan |
|---|
| Article MeSH List: | Adult; Animals; Antigens, Protozoan(genetics; immunology); Female; Genes, MHC Class I; HLA Antigens(genetics); Humans; Immunization Schedule; Malaria Vaccines(genetics; immunology); Male; Plasmodium falciparum(genetics; immunology); Protozoan Proteins(genetics; immunology); T-Lymphocytes, Cytotoxic(immunology); Vaccination; Vaccines, DNA(immunology) |
|---|
| Curation Last Updated: | 2013-06-05 15:48:05 |
|---|
