Epitopes described in "Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine."

Article Authors:R Wang; D L Doolan; T P Le; R C Hedstrom; K M Coonan; Y Charoenvit; T R Jones; P Hobart; M Margalith; J Ng; W R Weiss; M Sedegah; C de Taisne; J A Norman; S L Hoffman
Article Title:Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.
Reference Detail
Reference ID:1002777
Abstract:CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8+ T cell responses. Malaria-naïve volunteers who were vaccinated with plasmid DNA encoding a malaria protein developed antigen-specific, genetically restricted, CD8+ T cell-dependent CTLs. Responses were directed against all 10 peptides tested and were restricted by six human lymphocyte antigen (HLA) class I alleles. This first demonstration in healthy naïve humans of the induction of CD8+ CTLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology.
Affiliations:Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889-5607, USA.
Reference Type:Literature
PubMed ID:9774275
Journal Volume:282
Article Pages:476-80
Journal ISSN:1095-9203
Article Chemical List:Antigens, Protozoan;HLA Antigens;Malaria Vaccines;Protozoan Proteins;Vaccines, DNA;circumsporozoite protein, Protozoan
Article MeSH List:Adult; Animals; Antigens, Protozoan(genetics; immunology); Female; Genes, MHC Class I; HLA Antigens(genetics); Humans; Immunization Schedule; Malaria Vaccines(genetics; immunology); Male; Plasmodium falciparum(genetics; immunology); Protozoan Proteins(genetics; immunology); T-Lymphocytes, Cytotoxic(immunology); Vaccination; Vaccines, DNA(immunology)
Curation Last Updated:2016-01-06 18:19:36