Epitopes described in "The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism."

Article Authors:J M den Haan; L M Meadows; W Wang; J Pool; E Blokland; T L Bishop; C Reinhardus; J Shabanowitz; R Offringa; D F Hunt; V H Engelhard; E Goulmy
Article Title:The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.
Reference Detail
Reference ID:315241
Abstract:The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GvHD development.
Affiliations:Department of Immunohematology and Bloodbank, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Reference Type:Literature
PubMed ID:9461441
Journal Volume:279
Article Pages:1054-7
Journal ISSN:1095-9203
Article Chemical List:HA-1 antigen;HLA-A Antigens;Minor Histocompatibility Antigens;Oligopeptides
Article MeSH List:Alleles; Amino Acid Sequence; Bone Marrow Transplantation(adverse effects); Cell Line; Cell Line, Transformed; Female; Graft vs Host Disease(immunology); HLA-A Antigens(immunology); Histocompatibility Testing; Humans; Male; Mass Spectrometry; Minor Histocompatibility Antigens(chemistry; genetics; immunology); Minor Histocompatibility Loci; Oligopeptides(chemistry; genetics; immunology); Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; T-Lymphocytes, Cytotoxic(immunology)
Article Comments:Data originally imported from the Database of Functional Molecular Immunology, FIMM (http://sdmc.lit.org.sg:8080/fimm/)
Curation Last Updated:2014-10-03 19:44:14