Epitopes described in "Impaired Th2 subset development in the absence of CD4."

Article Authors:D J Fowell; J Magram; C W Turck; N Killeen; R M Locksley
Article Title:Impaired Th2 subset development in the absence of CD4.
Reference Detail
Reference ID:1003762
Abstract:Prior studies in CD4-deficient mice established the capacity of T helper (Th) lineage cells to mature into Th1 cells. Unexpectedly, challenge of these mice with Nippostrongylus brasiliensis, a Th2-inducing stimulus, failed to result in the development of Th2 cells. Additional studies were performed using CD4+ or CD4-CD8- (double-negative) T cell receptor (TCR) transgenic T cells reactive to LACK antigen of Leishmania major. Double-negative T cells were unable to develop into Th2 cells in vivo, and, unlike CD4+ T cells, could not be primed for interleukin-4 production in vitro. Similarly, CD4+ TCR transgenic T cells primed on antigen-presenting cells expressing mutant MHC class II molecules unable to bind CD4 did not differentiate into Th2 cells. These data suggest that interactions between the TCR, MHC II-peptide complex and CD4 may be involved in Th2 development.
Affiliations:Department of Medicine, University of California, San Francisco, 94143, USA.
Reference Type:Literature
PubMed ID:9175834
Journal Volume:6
Article Pages:559-69
Journal ISSN:1074-7613
Article Chemical List:Antigens, CD4;Histocompatibility Antigens Class II;Receptors, Antigen, T-Cell;Interleukin-4
Article MeSH List:Animals; Antigen-Presenting Cells(metabolism); Antigens, CD4(genetics; metabolism); Cell Differentiation(genetics; immunology); Cells, Cultured; Female; Histocompatibility Antigens Class II(genetics); Interleukin-4(biosynthesis); Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation; Protein Binding(genetics; immunology); Receptors, Antigen, T-Cell(genetics); Th2 Cells(immunology; metabolism; pathology); Transgenes(immunology)
Curation Last Updated:2015-07-30 20:15:13