Epitopes described in "An H-YDb epitope is encoded by a novel mouse Y chromosome gene."

Article Authors:A Greenfield; D Scott; D Pennisi; I Ehrmann; P Ellis; L Cooper; E Simpson; P Koopman
Article Title:An H-YDb epitope is encoded by a novel mouse Y chromosome gene.
Reference Detail
Reference ID:1020150
Abstract:Rejection of male tissue grafts by genotypically identical female mice has been explained by the existence of a male-specific transplantation antigen, H-Y (ref. 1), but the molecular nature of H-Y antigen has remained obscure. Hya, the murine locus controlling H-Y expression, has been localized to delta Sxrb, a deletion interval of the short arm of the Y chromosome. In mice, H-Y antigen comprises at least four distinct epitopes, each recognized by a specific T lymphocyte clone. It has recently been shown that one of these epitopes, H-YKk, is a peptide encoded by the Y-linked Smcy gene, presented at the cell surface with the H-2Kk major histocompatibility complex (MHC) molecule. However, deletion mapping and the analysis of variable inactivation of H-Y epitopes has suggested that the Hya locus may be genetically complex. Here we describe a novel mouse Y chromosome gene which we call Uty (ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome). We identify the peptide WMHHNMDLI derived from the UTY protein as an H-Y epitope, H-YDb. Our data formally demonstrate that H-Y antigen is the product of more than one gene on the Y chromosome.
Affiliations:Centre for Molecular & Cellular Biology, University of Queensland, Brisbane, Australia. a.greenfield@har.mrc.ac.uk
Reference Type:Literature
PubMed ID:8944031
Journal:Nat Genet
Journal Volume:14
Article Pages:474-8
Journal ISSN:1061-4036
Article Chemical List:Epitopes;H-Y Antigen;Proteins;Uty protein, mouse
Article MeSH List:Amino Acid Sequence; Animals; Blotting, Southern; Cell Line; Chromosome Mapping; Cloning, Molecular; Epitopes(biosynthesis; genetics); Female; Fetus(metabolism); H-Y Antigen(biosynthesis; genetics); Male; Mice; Molecular Sequence Data; Polymerase Chain Reaction; Proteins(genetics; immunology); Sex Characteristics; Transfection; Y Chromosome
Curation Last Updated:2015-07-30 20:37:02