Epitopes described in "Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen."

Reference
Article Authors:T S Jardetzky; J H Brown; J C Gorga; L J Stern; R G Urban; Y I Chi; C Stauffacher; J L Strominger; D C Wiley
Article Title:Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.
Reference Detail
Reference ID:1070
Abstract:The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a human class II histocompatibility complex molecule (HLA-DR1) has been determined by X-ray crystallography. The superantigen binds as an intact protein outside the conventional peptide antigen-binding site of the class II major histocompatibility complex (MHC) molecule. No large conformational changes occur upon complex formation in either the DR1 or the enterotoxin B molecules. The structure of the complex helps explain how different class II molecules and superantigens associate and suggests a model for ternary complex formation with the T-cell antigen receptor (TCR), in which unconventional TCR-MHC contacts are possible.
Affiliations:Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
Date:1994
Reference Type:Literature
PubMed ID:8152483
Journal:Nature
Journal Volume:368
Article Pages:711-8
Journal ISSN:1476-4687
Article Chemical List:Enterotoxins;HLA-DR1 Antigen;Macromolecular Substances;Receptors, Antigen, T-Cell;Superantigens;enterotoxin B, staphylococcal
Article MeSH List:Amino Acid Sequence; Animals; Crystallography, X-Ray; Enterotoxins(chemistry; immunology); HLA-DR1 Antigen(chemistry); Humans; Macromolecular Substances; Mice; Models, Molecular; Molecular Sequence Data; Receptors, Antigen, T-Cell(metabolism); Staphylococcus aureus(immunology); Superantigens(chemistry; immunology)
Curation Last Updated:2014-07-16 20:07:56