Epitopes described in "Induction of allograft tolerance in rats by an HLA class-I-derived peptide and cyclosporine A."

Article Authors:S Nisco; P Vriens; G Hoyt; S C Lyu; F Farfan; P Pouletty; A M Krensky; C Clayberger
Article Title:Induction of allograft tolerance in rats by an HLA class-I-derived peptide and cyclosporine A.
Reference Detail
Reference ID:1020449
Abstract:T cell recognition of MHC molecules initiates a cascade of events resulting in allograft rejection. CTLs damage the graft by targeting nonself-MHC class I molecules. We and others have previously shown that small synthetic peptides corresponding to regions of certain MHC class I molecules can inhibit the CTL response against MHC class I alloantigens in vitro. Here we report that rat heart allografts survived survived indefinitely when transplanted into recipients treated with a synthetic peptide corresponding to residues 75-84 of (B7.75-84) in combination with a subtherapeutic dose of cyclosporine A. Furthermore, this treatment induced long-term donor-specific tolerance that was mediated by anergic cells, indicating that such peptides may have potential as therapeutics for human organ transplantation.
Reference Type:Literature
PubMed ID:8144948
Journal:J Immunol
Journal Volume:152
Article Pages:3786-92
Journal ISSN:0022-1767
Article Chemical List:HLA-B7 Antigen;Histocompatibility Antigens Class I;Peptides;Cyclosporine
Article MeSH List:Amino Acid Sequence; Animals; Cyclosporine(pharmacology); Cytotoxicity, Immunologic; Graft Survival(drug effects); HLA-B7 Antigen(immunology); Heart Transplantation(immunology); Histocompatibility Antigens Class I(immunology); Immune Tolerance; Male; Molecular Sequence Data; Peptides(chemistry; immunology); Rats; Rats, Inbred Strains; T-Lymphocytes, Cytotoxic(immunology)
Curation Last Updated:2014-10-03 22:11:20