Epitopes described in "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein."

Article Authors:W Wang; L R Meadows; J M den Haan; N E Sherman; Y Chen; E Blokland; J Shabanowitz; A I Agulnik; R C Hendrickson; C E Bishop
Article Title:Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein.
Reference Detail
Reference ID:315065
Abstract:H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.
Affiliations:Department of Microbiology, University of Virginia, Charlottesville 22908, USA.
Reference Type:Literature
PubMed ID:7667640
Journal Volume:269
Article Pages:1588-90
Journal ISSN:1095-9203
Article Chemical List:H-Y Antigen;HLA-B7 Antigen;Proteins;Histone Demethylases;KDM5D protein, human;KDM5C protein, human;Oxidoreductases, N-Demethylating;Histone-Lysine N-Methyltransferase
Article MeSH List:Amino Acid Sequence; B-Lymphocytes; Cell Line; Chromatography, High Pressure Liquid; H-Y Antigen(chemistry; genetics; immunology); HLA-B7 Antigen(immunology); Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Male; Mass Spectrometry(methods); Molecular Sequence Data; Molecular Weight; Oxidoreductases, N-Demethylating; Proteins(chemistry; genetics; immunology); T-Lymphocytes, Cytotoxic(immunology); X Chromosome; Y Chromosome
Article Comments:Data originally imported from the Database of Functional Molecular Immunology, FIMM (http://sdmc.lit.org.sg:8080/fimm/) and from the HLA Ligand Database (http://hlaligand.ouhsc.edu/)
Curation Last Updated:2014-10-03 19:43:39