Epitopes described in "Identification of a mouse male-specific transplantation antigen, H-Y."

Article Authors:D M Scott; I E Ehrmann; P S Ellis; C E Bishop; A I Agulnik; E Simpson; M J Mitchell
Article Title:Identification of a mouse male-specific transplantation antigen, H-Y.
Reference Detail
Reference ID:1020151
Abstract:The male-specific transplantation antigen, H-Y, causes rejection of male tissue grafts by genotypically identical female mice and contributes to the rejection of human leukocyte antigen-matched male organ grafts by human females. Although first recognized 40 years ago, the identity of H-Y has remained elusive. T cells detect several distinct H-Y epitopes, and these are probably peptides, derived from intracellular proteins, that are presented at the cell surface with major histocompatibility complex (MHC) molecules. In the mouse, the gene(s) controlling H-Y expression (Hya) are located on the short arm of the Y chromosome between the zinc-finger genes Zfy-1 and Zfy-2. We have recently identified Smcy, a ubiquitously expressed gene, in this region and its X-chromosome homologue, Smcx. Here we report that Smcy encodes an H-YKk epitope that is defined by the octamer peptide TENSGKDI: no similar peptide is found in Smcx. These findings provide a genetic basis for the antigenic difference between males and females that contributes towards a tissue transplant rejection response.
Affiliations:MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Reference Type:Literature
PubMed ID:7544442
Journal Volume:376
Article Pages:695-8
Journal ISSN:0028-0836
Article Chemical List:DNA-Binding Proteins;Epitopes;H-Y Antigen;Recombinant Proteins;Transcription Factors;Zfy1 protein, mouse;Zfy2 protein, mouse
Article MeSH List:Amino Acid Sequence; Animals; Cell Line; Chromosome Mapping; Cloning, Molecular; Cosmids; DNA-Binding Proteins(genetics); Epitopes(genetics); Female; Graft Rejection(immunology); H-Y Antigen(genetics; immunology); Male; Mice; Molecular Sequence Data; Recombinant Proteins; Sex Characteristics; T-Lymphocytes(immunology); Transcription Factors; X Chromosome; Y Chromosome; Zinc Fingers(genetics)
Curation Last Updated:2015-07-30 20:37:02