Epitopes described in "Identification of a graft versus host disease-associated human minor histocompatibility antigen."

Article Authors:J M den Haan; N E Sherman; E Blokland; E Huczko; F Koning; J W Drijfhout; J Skipper; J Shabanowitz; D F Hunt; V H Engelhard
Article Title:Identification of a graft versus host disease-associated human minor histocompatibility antigen.
Reference Detail
Reference ID:315047
Abstract:Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.
Affiliations:Department of Immunohaematology, University Hospital, Leiden, Netherlands.
Reference Type:Literature
PubMed ID:7539551
Journal Volume:268
Article Pages:1476-80
Journal ISSN:1095-9203
Article Chemical List:Epitopes;HA-2 antigen;HLA-A2 Antigen;Minor Histocompatibility Antigens;Neoplasm Proteins;Oligopeptides
Article MeSH List:Amino Acid Sequence; Bone Marrow Transplantation; Epitopes; Female; Graft vs Host Disease(immunology); HLA-A2 Antigen(immunology); Humans; Mass Spectrometry; Minor Histocompatibility Antigens(chemistry; immunology); Molecular Sequence Data; Neoplasm Proteins(chemistry; immunology); Oligopeptides(chemistry; immunology); T-Lymphocytes, Cytotoxic(immunology)
Article Comments:Data originally imported from the Database of Functional Molecular Immunology, FIMM (http://sdmc.lit.org.sg:8080/fimm/) and from the HLA Ligand Database (http://hlaligand.ouhsc.edu/)
Curation Last Updated:2014-10-03 19:43:33