Epitopes described in "HLA-A2 peptides can regulate cytolysis by human allogeneic T lymphocytes."

Article Authors:C Clayberger; P Parham; J Rothbard; D S Ludwig; G K Schoolnik; A M Krensky
Article Title:HLA-A2 peptides can regulate cytolysis by human allogeneic T lymphocytes.
Reference Detail
Reference ID:1020487
Abstract:The class-I and class-II molecules encoded by the major histocompatibility complex (MHC) are homologous proteins which allow cytotoxic and helper T cells to recognize foreign antigens. Recent studies have shown that the form of the antigen recognized by T cells is generally not a native protein but rather a short peptide fragment and that class-II molecules specifically bind antigenic peptides. Furthermore, the three-dimensional structure of the human MHC class-I molecule, HLA-A2, is consistent with a peptide-binding function for MHC class-I molecules. An outstanding question concerns the molecular nature and involvement of MHC-bound peptides in antigens recognized by alloreactive T cells. In this study the effects of peptides derived from HLA-A2 on cytolysis of alloreactive cytotoxic T cells (TC) cells are presented. Peptides can inhibit lysis by binding to the T cell or sensitize to lysis by binding an HLA-A2-related class-I molecule (HLA-Aw69) on the target cell. Thus, allospecific TC cells can recognize HLA-derived peptides in the context of the MHC.
Affiliations:Department of Pediatrics, Stanford University School of Medicine, California 94305.
Reference Type:Literature
PubMed ID:3501071
Journal Volume:330
Article Pages:763-5
Journal ISSN:0028-0836
Article Chemical List:HLA Antigens;HLA-A2 Antigen;Peptide Fragments
Article MeSH List:Clone Cells; Cytotoxicity, Immunologic; HLA Antigens(physiology); HLA-A2 Antigen; Humans; Peptide Fragments(immunology); T-Lymphocytes, Cytotoxic(immunology)
Curation Last Updated:2014-10-03 22:11:33