Epitopes described in "Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies."

Reference
Article Authors:R A Asherson; D Mercey; G Phillips; N Sheehan; A E Gharavi; E N Harris; G R Hughes
Article Title:Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies.
Reference Detail
Reference ID:1016333
Abstract:Four patients with recurrent stroke and multi-infarct dementia are presented in whom the dementia was progressive and severe. Three of the patients developed the dementia during the course of an illness which was punctuated by repeated episodes of cerebral infarction demonstrated by computed tomographic (CT) scans. The fourth patient presented with an illness dominated by progressive and deteriorating higher mental functions, which culminated in a major stroke 18 months later. Three patients fulfilled the American Rheumatism Association (ARA) criteria for the classification of systemic lupus erythematosus, the fourth had a 'lupus-like' disease. All had livedo reticularis, severe migraines, and also demonstrated antibodies to phospholipids. All four patients suffered deep vein thromboses.
Date:1987
Reference Type:Literature
PubMed ID:3116954
Journal:Ann Rheum Dis
Journal Volume:46
Article Pages:605-11
Journal ISSN:1468-2060
Article Chemical List:Autoantibodies;Blood Coagulation Factors;Cardiolipins;Lupus Coagulation Inhibitor;Phospholipids
Article MeSH List:Adult; Autoantibodies(analysis); Blood Coagulation Factors(analysis; immunology); Cardiolipins(analysis); Cerebrovascular Disorders(complications; immunology); Dementia(complications; immunology; radiography); Female; Humans; Lupus Coagulation Inhibitor; Lupus Erythematosus, Systemic(complications; immunology); Middle Aged; Phospholipids(immunology); Recurrence
Curation Last Updated:2014-04-11 20:11:31