Epitopes described in "Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2."

Article Authors:F Gotch; J Rothbard; K Howland; A Townsend; A McMichael
Article Title:Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2.
Reference Detail
Reference ID:1000124
Abstract:Both human and murine cytotoxic T cells (CTL) elicited in response to infection with influenza A viruses have been shown to be specific for internal viral proteins, such as the matrix and nucleoprotein. Individual CTL epitopes have been identified in the nucleoprotein by successfully substituting short synthetic peptides for the intact virus in the preparation of target cells in cytotoxicity assays. The defined peptide epitopes have each been recognized by CTL in association with individual class I major histocompatibility complex (MHC) proteins, H-2Db, H-2Kk, H-2Kd (Taylor, P. et al., unpublished data) and HLA-B37. A logical strategy to investigate the molecular details of the interaction between antigen and MHC class I proteins would be to define an epitope recognized by the MHC class I molecule HLA-A2. This is because the amino-acid sequence is known, several variants of A2 have been characterized and the protein has been purified and crystallized. Here we describe a peptide derived from the influenza matrix protein that is recognized by human CTL in association with the HLA-A2 molecule.
Reference Type:Literature
PubMed ID:2437457
Journal Volume:326
Article Pages:881-2
Journal ISSN:1476-4687
Article Chemical List:Antigens, Viral;Epitopes;HLA Antigens;HLA-A2 Antigen;M-protein, influenza virus;Membrane Proteins;Peptide Fragments;Viral Matrix Proteins;Viral Proteins
Article MeSH List:Animals; Antigens, Viral(chemical synthesis; immunology); Epitopes(immunology); HLA Antigens(immunology); HLA-A2 Antigen; Humans; Influenza A virus(immunology); Membrane Proteins(immunology; isolation & purification); Mice; Peptide Fragments(chemical synthesis; immunology); T-Lymphocytes, Cytotoxic(immunology); Viral Matrix Proteins; Viral Proteins(immunology; isolation & purification)
Curation Last Updated:2014-10-03 19:46:01