Epitopes described in "HTLV-1 bZIP factor-specific CD4 T cell responses in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation."

Article Authors:Tomoko Narita; Takashi Ishida; Ayako Masaki; Susumu Suzuki; Asahi Ito; Fumiko Mori; Tomiko Yamada; Masaki Ri; Shigeru Kusumoto; Hirokazu Komatsu; Yasuhiko Miyazaki; Yoshifusa Takatsuka; Atae Utsunomiya; Akio Niimi; Shinsuke Iida; Ryuzo Ueda
Article Title:HTLV-1 bZIP factor-specific CD4 T cell responses in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation.
Reference Detail
Reference ID:1027210
Abstract:We document human T lymphotropic virus type 1 (HTLV-1) bZIP factor (HBZ)-specific CD4 T cell responses in an adult T cell leukemia/lymphoma (ATL) patient after allogeneic hematopoietic stem cell transplantation (HCT) and identified a novel HLA-DRB1*15:01-restricted HBZ-derived naturally presented minimum epitope sequence, RRRAEKKAADVA (HBZ114-125). This peptide was also presented on HLA-DRB1*15:02, recognized by CD4 T cells. Notably, HBZ-specific CD4 T cell responses were only observed in ATL patients after allogeneic HCT (4 of 9 patients) and not in nontransplanted ATL patients (0 of 10 patients) or in asymptomatic HTLV-1 carriers (0 of 10 carriers). In addition, in one acute-type patient, HBZ-specific CD4 T cell responses were absent in complete remission before HCT, but they became detectable after allogeneic HCT. We surmise that HTLV-1 transmission from mothers to infants through breast milk in early life induces tolerance to HBZ and results in insufficient HBZ-specific T cell responses in HTLV-1 asymptomatic carriers or ATL patients. In contrast, after allogeneic HCT, the reconstituted immune system from donor-derived cells can recognize virus protein HBZ as foreign, and HBZ-specific immune responses are provoked that contribute to the graft-versus-HTLV-1 effect.
Reference Type:Literature
PubMed ID:24363428
Journal:J Immunol
Journal Volume:192
Article Pages:940-7
Journal ISSN:0022-1767
Article Chemical List:Basic-Leucine Zipper Transcription Factors;Epitopes, T-Lymphocyte;HBZ protein, human T-cell leukemia virus type I;HLA-D Antigens;HTLV-I Antigens;Peptide Fragments;Tumor Necrosis Factor-alpha;Viral Proteins;Interferon-gamma
Article MeSH List:Allografts; Amino Acid Sequence; Asymptomatic Diseases; Basic-Leucine Zipper Transcription Factors(chemistry; immunology); CD4-Positive T-Lymphocytes(immunology); CD8-Positive T-Lymphocytes(immunology); Carrier State(immunology); Cell Line; Epitopes, T-Lymphocyte(chemistry; immunology); Female; Genotype; Graft vs Leukemia Effect(immunology); HLA-D Antigens(genetics; immunology); HTLV-I Antigens(immunology); Hematopoietic Stem Cell Transplantation; Human T-lymphotropic virus 1(immunology); Humans; Interferon-gamma(biosynthesis); Leukemia-Lymphoma, Adult T-Cell(immunology; surgery); Male; Molecular Sequence Data; Peptide Fragments(chemical synthesis; immunology); Tumor Necrosis Factor-alpha(biosynthesis); Viral Proteins(chemistry; immunology)
Curation Last Updated:2015-07-24 20:11:28