Epitopes described in "Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the alpha 2 domain of HLA-A2."

Article Authors:P Parham; C Clayberger; S L Zorn; D S Ludwig; G K Schoolnik; A M Krensky
Article Title:Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the alpha 2 domain of HLA-A2.
Reference Detail
Reference ID:1020486
Abstract:Class I major histocompatibility complex (MHC) molecules function in the recognition of antigens by cytotoxic T lymphocytes (CTL). Although this biological role is firmly established and much has been learnt about their structure and polymorphic variation, little is known of the regions of class I molecules that are involved in functional interactions with components of the T-cell surface. Here we show that peptides derived from residues 98-113 of the alpha 2 domain of HLA-A2 specifically inhibit the recognition of target cells by many HLA-A2-specific CTL. In addition to identifying a region that is probably involved in binding the T-cell receptor these results raise the possibility that alloreactive CTL may recognize degraded fragments of class I histocompatibility antigens.
Reference Type:Literature
PubMed ID:2433598
Journal Volume:325
Article Pages:625-8
Journal ISSN:0028-0836
Article Chemical List:Epitopes;HLA Antigens;HLA-A2 Antigen;Peptides;Endopeptidases;Chymotrypsin;Endopeptidase K
Article MeSH List:Amino Acid Sequence; Chymotrypsin(pharmacology); Endopeptidase K; Endopeptidases(pharmacology); Epitopes(immunology); HLA Antigens(analysis); HLA-A2 Antigen; Peptides(analysis); T-Lymphocytes, Cytotoxic(immunology)
Curation Last Updated:2015-01-27 21:52:00