Epitopes described in "Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine."

Reference
Article Authors:Christopher E Martin; Felix Broecker; Steffen Eller; Matthias A Oberli; Chakkumkal Anish; Claney L Pereira; Peter H Seeberger
Article Title:Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine.
Reference Detail
Reference ID:1026478
Abstract:Clostridium difficile is a leading cause of severe nosocomial infections. Cell-surface carbohydrate antigens are promising vaccine candidates. Here we report the first total synthesis of oligomers of the lipoteichoic acid antigen repeating unit. Synthetic glycan microarrays revealed anti-glycan antibodies in the blood of patients that help to define epitopes for vaccine development.
Date:2013
Reference Type:Literature
PubMed ID:23836132
Journal:Chem Commun (Camb)
Journal Volume:49
Article Pages:7159-61
Journal ISSN:1364-548X
Article Chemical List:Bacterial Vaccines;Lipopolysaccharides;Polysaccharides;Teichoic Acids;lipoteichoic acid
Article MeSH List:Bacterial Vaccines(chemical synthesis; chemistry; pharmacology); Clostridium difficile(drug effects); Humans; Lipopolysaccharides(chemical synthesis; chemistry); Microarray Analysis; Polysaccharides(chemistry; pharmacology; therapeutic use); Teichoic Acids(chemical synthesis; chemistry)
Curation Last Updated:2014-09-11 20:14:59