Epitopes described in "Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin."

Article Authors:Jennifer L Nayak; Shabnam Alam; Andrea J Sant
Article Title:Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin.
Reference Detail
Reference ID:1026637
Abstract:Influenza-specific immunity in humans is unique because there are repeated exposures to viral strains containing genetically conserved epitopes recruiting memory CD4 T cells and novel epitopes stimulating naive CD4 T cells, possibly resulting in competition between memory and naive lymphocytes. In this study, we evaluated the effect of this competition on CD4 T cell and B cell response specificity using a murine model of sequential influenza infection. We found striking and selective decreases in CD4 T cell reactivity to nonconserved hemagglutinin (HA) epitopes following secondary influenza infection. Surprisingly, this shift in CD4 T cell specificity was associated with dramatic decreases in HA-specific Ab. These results suggest that repeated exposure to influenza viruses and vaccines containing conserved internal proteins may have unintended and negative consequences on the ability to induce HA-specific Ab to novel pandemic strains of influenza. These finding could have important implications on pandemic influenza preparedness strategies.
Affiliations:Division of Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Reference Type:Literature
PubMed ID:23794632
Journal:J Immunol
Journal Volume:191
Article Pages:1001-5
Journal ISSN:0022-1767
Article Chemical List:Antibodies, Viral;Epitopes, T-Lymphocyte;Hemagglutinin Glycoproteins, Influenza Virus
Article MeSH List:Animals; Antibodies, Viral(immunology); Antibody Specificity; B-Lymphocytes(immunology); CD4-Positive T-Lymphocytes(immunology); Epitopes, T-Lymphocyte(immunology); Hemagglutinin Glycoproteins, Influenza Virus(immunology); Influenza A Virus, H1N1 Subtype(immunology); Influenza A Virus, H3N2 Subtype(immunology); Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections(immunology; prevention & control; virology)
Curation Last Updated:2015-07-30 20:48:30