Epitopes described in "Conserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian populations."

Article Authors:Jun Liu; Bin Wu; Shihong Zhang; Shuguang Tan; Yeping Sun; Zhujun Chen; Yuanfang Qin; Mingwei Sun; Guoli Shi; Ying Wu; Meiyi Sun; Na Liu; Kaida Ning; Ying Ma; Bin Gao; Jinghua Yan; Fengcai Zhu; Hua Wang; George F Gao
Article Title:Conserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian populations.
Reference Detail
Reference ID:1026677
Abstract:Novel strains of influenza A viruses (IAVs) have emerged with high infectivity and/or pathogenicity in recent years, causing worldwide concern. T cells are correlated with protection in humans through cross-reactive immunity against heterosubtypes of IAV. However, the different hierarchical roles of IAV-derived epitopes with distinct levels of polymorphism in the cross-reactive T-cell responses against IAV remain elusive. In this study, immunodominant epitopes scattered throughout the entire proteome of 2009 pandemic influenza A H1N1 virus and seasonal IAVs were synthesized and divided into different pools depending on their conservation. The overall profile of the IAV-specific CD8(+) T-cell immunity was detected by utilizing these peptide pools and also individual peptides. A dominant role of the conserved peptide-specific T-cell immunity was illuminated within the anti-IAV responses, while the CD8(+) T-cell responses against the variable epitopes were lower than the conserved peptides. As previously demonstrated within a Caucasian population, we determined that GL9-specific T cells, which also utilize V 17 TCR (BV19), play a pivotal role in IAV-specific T-cell immunity within an HLA-A2(+) Asian population. Our study objectively reveals the different predominant roles of T-cell epitopes among IAV-specific cross-reactive cellular immunity. This may guide the development of vaccines with cross-T-cell immunogenicity against heterosubtypes of IAV.
Reference Type:Literature
PubMed ID:23681926
Journal:Eur J Immunol
Journal Volume:43
Article Pages:2055-69
Journal ISSN:0014-2980
Article Chemical List:Epitopes, T-Lymphocyte;HLA-A2 Antigen;Proteome;Receptors, Antigen, T-Cell;Viral Proteins
Article MeSH List:Adult; Antigenic Variation; Asia; CD8-Positive T-Lymphocytes(immunology); Cell Line; Epitopes, T-Lymphocyte(genetics; immunology); Female; HLA-A2 Antigen(immunology); Humans; Influenza A Virus, H1N1 Subtype(immunology); Influenza, Human(immunology; virology); Male; Middle Aged; Proteome; Receptors, Antigen, T-Cell(immunology); Viral Proteins(immunology); Young Adult
Curation Last Updated:2014-10-03 22:57:04