Epitopes described in "Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy."

Reference
Article Authors:C Hamsten; M Starkhammar; T A T Tran; M Johansson; U Bengtsson; G Ahlén; M Sällberg; H Grönlund; M van Hage
Article Title:Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy.
Reference Detail
Reference ID:1025636
Abstract:Patients with IgE antibodies against the carbohydrate epitope galactose--1,3-galactose (-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to -Gal and tick bites. We provide the first direct evidence that -Gal is present within ticks thus potentially explaining the relationship between tick exposure and sensitization to -Gal, with development of red meat allergy as a secondary phenomena. Serum from Swedish patients with delayed severe reactions to red meat was included in the study. A dose-dependent inhibition of IgE responses to -Gal by the tick Ixodes ricinus is demonstrated. Furthermore, using cryostat-cut sections of I. ricinus, we show that both a monoclonal and a polyclonal antibody against -Gal stains the gastrointestinal tract of the tick. The same pattern is seen when staining with patient sera IgE positive to -Gal. These results confirm that the -Gal epitope is present in I. ricinus and imply host exposure to -Gal during a tick bite. This provides further evidence that tick bites are associated with IgE responses to -Gal and red meat allergy.
Date:2013
Reference Type:Literature
PubMed ID:23414348
Journal:Allergy
Journal Volume:68
Article Pages:549-52
Journal ISSN:1398-9995
Article Chemical List:Allergens;Disaccharides;Epitopes;galactosyl-(1-3)galactose;Immunoglobulin E
Article MeSH List:Adult; Allergens(immunology); Animals; Cattle; Chickens; Disaccharides(immunology); Epitopes(immunology); Female; Food Hypersensitivity(immunology); Gastrointestinal Tract(immunology); Humans; Immunoglobulin E(blood; immunology); Ixodes(immunology); Male; Meat Products(adverse effects); Middle Aged
Curation Last Updated:2014-10-11 20:14:57