Epitopes described in "CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation."

Article Authors:Ryan W Nelson; James B McLachlan; Jonathan R Kurtz; Marc K Jenkins
Article Title:CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.
Reference Detail
Reference ID:1025604
Abstract:CD4(+) memory-phenotype T cells decline over time when generated in response to acute infections cleared by other components of the immune system. Therefore, it was of interest to assess the stability of CD4(+) T cells during a persistent Salmonella infection, which is typical of persistent phagocytic infections that are controlled by this lymphocyte subset. We found that CD4(+) T cells specific for Salmonella peptide:MHC class II (MHCII) ligands were numerically stable for >1 y after initial oral infection. This stability was associated with peptide:MHCII-driven proliferation by a small number of T cells in the secondary lymphoid organs that harbored bacteria. The persistent population consisted of multifunctional Th1 cells that induced PD-1 and became exhausted when transferred to hosts expressing the specific peptide:MHCII ligand in all parts of the body. Thus, persistent infection of phagocytes produced a CD4(+) T cell population that was stably maintained by low-level peptide:MHCII presentation.
Affiliations:Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Reference Type:Literature
PubMed ID:23382562
Journal:J Immunol
Journal Volume:190
Article Pages:2828-34
Journal ISSN:0022-1767
Article Chemical List:Epitopes, T-Lymphocyte;Histocompatibility Antigens Class II;I-A(b) antigen, mouse;Peptide Fragments
Article MeSH List:Amino Acid Sequence; Animals; Antigen Presentation(genetics; immunology); CD4-Positive T-Lymphocytes(immunology; metabolism; microbiology); Cell Survival(genetics; immunology); Disease Models, Animal; Epitopes, T-Lymphocyte(genetics; metabolism); Female; Histocompatibility Antigens Class II(immunology; metabolism); Humans; Immunophenotyping(methods); Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Peptide Fragments(genetics; metabolism); Salmonella Infections(immunology; metabolism; pathology); Salmonella typhi(immunology)
Curation Last Updated:2015-07-30 20:47:08