Epitopes described in "Human T-cells directed to seasonal influenza A virus cross-react with 2009 pandemic influenza A (H1N1) and swine-origin triple-reassortant H3N2 influenza viruses."

Reference
Article Authors:Marine L B Hillaire; Stella E Vogelzang-van Trierum; Joost H C M Kreijtz; Gerrie de Mutsert; Ron A M Fouchier; Albert D M E Osterhaus; Guus F Rimmelzwaan
Article Title:Human T-cells directed to seasonal influenza A virus cross-react with 2009 pandemic influenza A (H1N1) and swine-origin triple-reassortant H3N2 influenza viruses.
Reference Detail
Reference ID:1025740
Abstract:Virus-specific CD8(+) T-cells contribute to protective immunity against influenza A virus (IAV) infections. As the majority of these cells are directed to conserved viral proteins, they may afford protection against IAVs of various subtypes. The present study assessed the cross-reactivity of human CD8(+) T-lymphocytes, induced by infection with seasonal A (H1N1) or A (H3N2) influenza virus, with 2009 pandemic influenza A (H1N1) virus [A(H1N1)pdm09] and swine-origin triple-reassortant A (H3N2) [A(H3N2)v] viruses that are currently causing an increasing number of human cases in the USA. It was demonstrated that CD8(+) T-cells induced after seasonal IAV infections exerted lytic activity and produced gamma interferon upon in vitro restimulation with A(H1N1)pdm09 and A(H3N2)v influenza A viruses. Furthermore, CD8(+) T-cells directed to A(H1N1)pdm09 virus displayed a high degree of cross-reactivity with A(H3N2)v viruses. It was concluded that cross-reacting T-cells had the potential to afford protective immunity against A(H1N1)pdm09 viruses during the pandemic and offer some degree of protection against infection with A(H3N2)v viruses.
Affiliations:Department of Viroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Date:2013
Reference Type:Literature
PubMed ID:23152369
Journal:J Gen Virol
Journal Volume:94
Article Pages:583-92
Journal ISSN:1465-2099
Article Chemical List:Epitopes
Article MeSH List:Amino Acid Sequence; Animals; CD8-Positive T-Lymphocytes(immunology; physiology); Cell Line, Tumor; Epitopes; Genetic Variation; Humans; Influenza A Virus, H1N1 Subtype(immunology); Influenza A Virus, H3N2 Subtype(immunology); Influenza A virus(immunology); Influenza, Human(immunology; virology); Orthomyxoviridae Infections(immunology; veterinary; virology); Pandemics
Curation Last Updated:2013-09-09 20:05:17