Epitopes described in "Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming."

Article Authors:Maria D Gainey; Joshua G Rivenbark; Hyelim Cho; Liping Yang; Wayne M Yokoyama
Article Title:Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming.
Reference Detail
Reference ID:1026061
Abstract:Although viral MHC class I inhibition is considered a classic immune-evasion strategy, its in vivo role is largely unclear. Mutant cowpox virus lacking its MHC class I inhibitors is markedly attenuated during acute infection because of CD8(+) T-cell-dependent control, but it was not known how CD8(+) T-cell responses are affected. Interestingly, we found no major effect of MHC class I down-regulation on priming of functional cowpox virus-specific CD8(+) T cells. Instead, we demonstrate that, during acute infection in vivo, MHC class I down-regulation prevents primed virus-specific CD8(+) T cells from recognizing infected cells and exerting effector responses to control the infection.
Affiliations:Rheumatology Division, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Reference Type:Literature
PubMed ID:23112205
Journal:Proc Natl Acad Sci U S A
Journal Volume:109
Article Pages:E3260-7
Journal ISSN:0027-8424
Article Chemical List:Histocompatibility Antigens Class I;Interferon-gamma
Article MeSH List:Animals; CD8-Positive T-Lymphocytes(immunology; virology); Cowpox(immunology; virology); Cowpox virus(immunology); Cross-Priming(immunology); Down-Regulation(immunology); Histocompatibility Antigens Class I(immunology); Interferon-gamma(biosynthesis); Lung(immunology; pathology; virology); Mice; Mice, Inbred C57BL; Mutation(genetics); Species Specificity
Curation Last Updated:2015-07-30 20:47:57