Epitopes described in "Subsets of nonclonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells."

Article Authors:Nevil J Singh; Jennifer K Bando; Ronald H Schwartz
Article Title:Subsets of nonclonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells.
Reference Detail
Reference ID:1025193
Abstract:After an immune response, the expanded population of antigen-specific CD4(+) T cells contract to steady state levels. We have found that the contraction is neither cell-autonomous nor mediated by competition for generic trophic factors, but regulated by relatively rare subsets of neighboring CD4(+) T cells not necessarily of a conventional regulatory T cell lineage. These regulators, referred to as deletors, specifically limit the frequency of particular antigen-specific T cells even though they are not reactive to the same agonist as their targets. Instead, an isolated deletor could outcompete the target for recognition of a shared, nonstimulatory endogenous peptide-MHC ligand. This mechanism was sufficient to prevent even agonist-driven autoimmune disease in a lymphopenic environment. Such a targeted regulation of homeostasis within narrow colonies of T cells with related TCR specificities for subthreshold ligands might help to prevent the loss of unrelated TCRs during multiple responses, preserving the valuable diversity of the repertoire.
Affiliations:Laboratory of Cellular and Molecular Immunology, NIAID, NIH, Bethesda, MD 20892, USA. ns117r@nih.gov.
Reference Type:Literature
PubMed ID:23021952
Journal Volume:37
Article Pages:735-46
Journal ISSN:1074-7613
Article Chemical List:gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@5f3e8a31;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@2e2c7d1;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@76ac6bd1
Article MeSH List:Animals; Antigens(immunology); Autoimmunity; CD4-Positive T-Lymphocytes(immunology); Cell Survival; Cells, Cultured; Ligands; Lymphopenia(immunology); Mice; Receptors, Antigen, T-Cell(immunology); T-Cell Antigen Receptor Specificity
Curation Last Updated:2015-01-18 00:34:14