Epitopes described in "Epitope-specific immune tolerization ameliorates experimental autoimmune encephalomyelitis."

Article Authors:Rosario Billetta; Negar Ghahramani; Olivia Morrow; Berent Prakken; Huib de Jong; Carol Meschter; Paola Lanza; Salvatore Albani
Article Title:Epitope-specific immune tolerization ameliorates experimental autoimmune encephalomyelitis.
Reference Detail
Reference ID:1025230
Abstract:The availability of glatiramer acetate (GA) for inducing immune tolerance is a significant advancement in the treatment of multiple sclerosis (MS). However, a sizable proportion of patients maintain active disease, regardless of treatment. Another approach to induce T-cell tolerance is therefore still an unmet medical need. We hypothesized that induction of mucosal tolerance toward a pro-inflammatory T-cell epitope derived from a heat shock protein (HSP) (RatP2) could translate into clinical benefit. We found that treatment of experimental autoimmune encephalomyelitis (EAE, a model of MS) with the peptide RatP2 determined a significant clinical improvement, which was comparable to the standard tolerization treatment (an MBP-derived peptide pool) and superior to GA. Histological analysis demonstrated a reduction of brain and spinal cord inflammatory lesions in treated animals. Moreover, with immunological analysis we identified biomarkers associated with clinical response. This work provides proof-of-concept to support the further testing of this approach as a possible complement to currently available therapies for MS.
Affiliations:Kai BioEnergy, 3525-723 Del Mar Heights Road, San Diego, CA 92130, USA.
Reference Type:Literature
PubMed ID:22982294
Journal:Clin Immunol
Journal Volume:145
Article Pages:94-101
Journal ISSN:1521-6616
Article Chemical List:Epitopes, T-Lymphocyte;Heat-Shock Proteins;Peptide Fragments;Peptides;copolymer 1
Article MeSH List:Amino Acid Sequence; Animals; Brain(drug effects; immunology; pathology); Encephalomyelitis, Autoimmune, Experimental(drug therapy; immunology; pathology); Epitopes, T-Lymphocyte(immunology); Female; Heat-Shock Proteins(chemistry; immunology); Humans; Immune Tolerance; Immunity, Mucosal; Molecular Sequence Data; Multiple Sclerosis(drug therapy; immunology; pathology); Peptide Fragments(chemical synthesis; immunology; pharmacology); Peptides(immunology; pharmacology); Rats; Rats, Inbred Lew; Spinal Cord(drug effects; immunology; pathology); T-Lymphocytes(drug effects; immunology; metabolism)
Curation Last Updated:2015-06-16 21:49:37