Epitopes described in "Chagasic patients are able to respond against a viral antigen from influenza virus."

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Article Authors:Paola Lasso; Diana Mesa; Natalia Bolaños; Adriana Cuéllar; Fanny Guzmán; Zulma Cucunuba; Fernando Rosas; Víctor Velasco; Maria C Thomas; Manuel Carlos López; John Mario González; Concepción Judith Puerta
Article Title:Chagasic patients are able to respond against a viral antigen from influenza virus.
Reference Detail
Reference ID:1025320
Abstract:BACKGROUND: Trypanosoma cruzi, the etiological agent of Chagas' disease, is an obligate intracellular parasite which induces a CD8+ T cell immune response with secretion of cytokines and release of cytotoxic granules. Although an immune-suppressive effect of T. cruzi on the acute phase of the disease has been described, little is known about the capacity of CD8+ T cell from chronic chagasic patients to respond to a non-T. cruzi microbial antigen. METHODS: In the present paper, the frequency, phenotype and the functional activity of the CD8+ T cells specific from Flu-MP*, an influenza virus epitope, were determined in 13 chagasic patients and 5 healthy donors. RESULTS: The results show that Flu-MP* peptide specific CD8+ T cells were found with similar frequencies in both groups. In addition, Flu-MP* specific CD8+ T cells were distributed in the early or intermediate/late differentiation stages without showing enrichment of a specific sub-population. The mentioned Flu-MP* specific CD8+ T cells from chagasic patients were predominately TEM (CCR7- CD62L-), producing IL-2, IFN, CD107a/b and perforin, and did not present significant differences when compared with those from healthy donors. CONCLUSIONS: Our results support the hypothesis that there is no CD8+ T cell nonspecific immune-suppression during chronic Chagas disease infection. Nonetheless, other viral antigens must be studied in order to confirm our findings.
Date:2012
Reference Type:Literature
PubMed ID:22920436
Journal:BMC Infect Dis
Journal Volume:12
Article Pages:198
Journal ISSN:1471-2334
Article Chemical List:Antigens, Viral;Interleukin-2;Lysosomal-Associated Membrane Protein 1;Lysosomal-Associated Membrane Protein 2;Perforin;Interferon-gamma
Article MeSH List:Antigens, Viral(immunology); CD8-Positive T-Lymphocytes(immunology); Chagas Disease(immunology); Humans; Immune Tolerance; Interferon-gamma(secretion); Interleukin-2(secretion); Lysosomal-Associated Membrane Protein 1(analysis); Lysosomal-Associated Membrane Protein 2(analysis); Orthomyxoviridae(immunology); Perforin(secretion); T-Lymphocyte Subsets(immunology); Trypanosoma cruzi(pathogenicity)
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