Epitopes described in "Highly conserved protective epitopes on influenza B viruses."

Article Authors:Cyrille Dreyfus; Nick S Laursen; Ted Kwaks; David Zuijdgeest; Reza Khayat; Damian C Ekiert; Jeong Hyun Lee; Zoltan Metlagel; Miriam V Bujny; Mandy Jongeneelen; Remko van der Vlugt; Mohammed Lamrani; Hans J W M Korse; Eric Geelen; Özcan Sahin; Martijn Sieuwerts; Just P J Brakenhoff; Ronald Vogels; Olive T W Li; Leo L M Poon; Malik Peiris; Wouter Koudstaal; Andrew B Ward; Ian A Wilson; Jaap Goudsmit; Robert H E Friesen
Article Title:Highly conserved protective epitopes on influenza B viruses.
Reference Detail
Reference ID:1025035
Abstract:Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.
Affiliations:Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Reference Type:Literature
PubMed ID:22878502
Journal Volume:337
Article Pages:1343-8
Journal ISSN:1095-9203
Article Chemical List:Antibodies, Monoclonal;Antibodies, Neutralizing;Hemagglutinin Glycoproteins, Influenza Virus;Immunodominant Epitopes;Influenza Vaccines;hemagglutinin HA1, influenza B virus
Article MeSH List:Amino Acid Sequence; Animals; Antibodies, Monoclonal(chemistry; immunology); Antibodies, Neutralizing(chemistry; immunology); Conserved Sequence; Hemagglutinin Glycoproteins, Influenza Virus(immunology); Humans; Immunodominant Epitopes(chemistry; immunology); Influenza B virus(immunology); Influenza Vaccines(immunology); Mice; Molecular Sequence Data; Neutralization Tests; Orthomyxoviridae Infections(prevention & control); Protein Conformation
Curation Last Updated:2016-03-22 17:54:19