Epitopes described in "Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection."

Article Authors:Min Fang; Nicholas A Siciliano; Adam R Hersperger; Felicia Roscoe; Angela Hu; Xueying Ma; Ahamed R Shamsedeen; Laurence C Eisenlohr; Luis J Sigal
Article Title:Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.
Reference Detail
Reference ID:1025991
Abstract:CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the mouse homolog of the human virus of smallpox, large numbers of CD4(+) T cells in the draining lymph node and liver of resistant mice have a cytotoxic phenotype. We also show that these cells kill targets in vivo in a perforin-dependent manner and that mice with specific deficiency of perforin in CD4(+) T cells have impaired virus control. Thus, perforin-dependent CD4(+) T-cell killing of infected cells is an important mechanism of antiviral defense.
Affiliations:Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Reference Type:Literature
PubMed ID:22665800
Journal:Proc Natl Acad Sci U S A
Journal Volume:109
Article Pages:9983-8
Journal ISSN:0027-8424
Article Chemical List:Perforin
Article MeSH List:Animals; CD4-Positive T-Lymphocytes(immunology); Cytotoxicity, Immunologic; Ectromelia virus(immunology); Major Histocompatibility Complex(immunology); Mice; Perforin(immunology)
Curation Last Updated:2015-07-30 20:47:47