Epitopes described in "IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression."

Article Authors:Michael Maes; Ivana Mihaylova; Marta Kubera; Jean-Claude Leunis; Frank N M Twisk; Michel Geffard
Article Title:IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.
Reference Detail
Reference ID:1025275
Abstract:Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and depression are considered to be neuro-immune disorders (Maes and Twisk, BMC Medicine 8:35, 2010). There is also evidence that depression and ME/CFS are accompanied by oxidative and nitrosative stress (O&NS) and by increased autoantibodies to a number of self-epitopes some of which have become immunogenic due to damage by O&NS. The aim of this study is to examine IgM-mediated autoimmune responses to different self-epitopes in ME/CFS versus depression. We examined serum IgM antibodies to three anchorage molecules (palmitic and myristic acid and S-farnesyl-L-cysteine); acetylcholine; and conjugated NO-modified adducts in 26 patients with major depression; 16 patients with ME/CFS, 15 with chronic fatigue; and 17 normal controls. Severity of fatigue and physio-somatic (F&S) symptoms was measured with the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale. Serum IgM antibodies to the three anchorage molecules and NO-phenylalanine were significantly higher in ME/CFS than in depression. The autoimmune responses to oxidatively, but not nitrosatively, modified self-epitopes were significantly higher in ME/CFS than in depression and were associated with F&S symptoms. The autoimmune activity directed against conjugated acetylcholine did not differ significantly between ME/CFS and depression, but was greater in the patients than controls. Partially overlapping pathways, i.e. increased IgM antibodies to a multitude of neo-epitopes, underpin both ME/CFS and depression, while greater autoimmune responses directed against anchorage molecules and oxidatively modified neo-epitopes discriminate patients with ME/CFS from those with depression. These autoimmune responses directed against neoantigenic determinants may play a role in the dysregulation of key cellular functions in both disorders, e.g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression.
Reference Type:Literature
PubMed ID:22614823
Journal:Metab Brain Dis
Journal Volume:27
Article Pages:415-23
Journal ISSN:0885-7490
Article Chemical List:Amino Acids;Epitopes;Immunoglobulin M;Myristic Acid;Palmitic Acid;Nitric Oxide;Phenylalanine;S-farnesylcysteine;Cysteine
Article MeSH List:Adult; Amino Acids(metabolism); Analysis of Variance; Autoimmune Diseases(immunology; psychology); Cysteine(analogs & derivatives; metabolism); Depressive Disorder, Major(immunology; psychology); Enzyme-Linked Immunosorbent Assay; Epitopes(immunology); Fatigue Syndrome, Chronic(immunology; psychology); Female; Humans; Immunoglobulin M(immunology); Least-Squares Analysis; Male; Middle Aged; Myristic Acid(metabolism); Nitric Oxide(metabolism); Palmitic Acid(metabolism); Phenylalanine(metabolism)
Curation Last Updated:2016-04-11 21:23:13