Epitopes described in "Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans."

Article Authors:Oludare A Odumade; Jennifer A Knight; David O Schmeling; David Masopust; Henry H Balfour Jr; Kristin A Hogquist
Article Title:Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans.
Reference Detail
Reference ID:1025988
Abstract:Acute Epstein-Barr virus (EBV) infection results in an unusually robust CD8(+) T cell response in young adults. Based on mouse studies, such a response would be predicted to result in attrition of preexisting memory to heterologous infections like influenza A (Flu) and cytomegalovirus (CMV). Furthermore, many studies have attempted to define the lymphocytosis that occurs during acute EBV infection in humans, but it is unclear whether bystander T cells contribute to it. To address these issues, we performed a longitudinal prospective study of primary EBV infection in humans. During acute EBV infection, both preexisting CMV- and Flu-specific memory CD8(+) T cells showed signs of bystander activation, including up-regulation of granzyme B. However, they generally did not expand, suggesting that the profound CD8(+) lymphocytosis associated with acute EBV infection is composed largely of EBV-specific T cells. Importantly, the numbers of CMV- and Flu-specific T cells were comparable before and after acute EBV infection. The data support the concept that, in humans, a robust CD8(+) T cell response creates a new memory CD8(+) T cell niche without substantially depleting preexisting memory for heterologous infections.
Affiliations:Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Reference Type:Literature
PubMed ID:22393125
Journal:J Exp Med
Journal Volume:209
Article Pages:471-8
Journal ISSN:0022-1007
Article MeSH List:CD8-Positive T-Lymphocytes(immunology); Cytomegalovirus Infections(complications; immunology); Epstein-Barr Virus Infections(complications; immunology); Humans; Immunologic Memory; Influenza A virus(immunology); Influenza, Human(complications; immunology); Longitudinal Studies; Lymphocyte Activation; Lymphocyte Count; Prospective Studies; Species Specificity; Young Adult
Curation Last Updated:2015-01-18 00:52:35