Epitopes described in "Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans."

Article Authors:Heather Friberg; Hema Bashyam; Tomoko Toyosaki-Maeda; James A Potts; Thomas Greenough; Siripen Kalayanarooj; Robert V Gibbons; Ananda Nisalak; Anon Srikiatkhachorn; Sharone Green; Henry A F Stephens; Alan L Rothman; Anuja Mathew
Article Title:Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans.
Reference Detail
Reference ID:1022829
Abstract:Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV) infection are thought to contribute to disease. However, epitope-specific T cell responses have not been thoroughly compared between subjects with primary versus secondary DENV infection. We studied CD8(+) T cells specific for the HLA-A*1101-restricted NS3(133) epitope in a cohort of A11(+) DENV-infected patients throughout acute illness and convalescence. We compared the expansion, serotype-cross-reactivity, and activation of these cells in PBMC from patients experiencing primary or secondary infection and mild or severe disease by flow cytometry. Our results show expansion and activation of DENV-specific CD8(+) T cells during acute infection, which are predominantly serotype-cross-reactive regardless of DENV infection history. These data confirm marked T cell activation and serotype-cross-reactivity during the febrile phase of dengue; however, A11-NS3(133)-specific responses did not correlate with prior antigenic exposure or current disease severity.
Affiliations:Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Reference Type:Literature
PubMed ID:22355570
Journal:Sci Rep
Journal Volume:1
Article Pages:51
Journal ISSN:2045-2322
Article MeSH List:CD8-Positive T-Lymphocytes(immunology); Child; Child, Preschool; Coinfection(immunology); Cross Reactions(immunology); Dengue(immunology; pathology); Humans; Infant; Infant, Newborn
Curation Last Updated:2015-01-18 00:14:05