Epitopes described in "Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)."

Reference
Article Authors:Derek J Abbott; J Lori Blanchfield; David A Martinson; Sean C Russell; Najla Taslim; Alan D Curtis; Mark D Mannie
Article Title:Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE).
Reference Detail
Reference ID:1022725
Abstract:BACKGROUND: Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in chronic murine models of experimental autoimmune encephalomyelitis (EAE) and thus serve as potential therapeutic modalities for multiple sclerosis. RESULTS: A fusion protein comprised of murine GM-CSF as the N-terminal domain and the encephalitogenic MOG35-55 peptide as the C-terminal domain was tested as a tolerogenic, therapeutic vaccine (TTV) in the C57BL/6 model of EAE. Administration of GMCSF-MOG before active induction of EAE, or alternatively, at the onset of EAE blocked the development and progression of EAE. Covalent linkage of the GM-CSF and MOG35-55 domains was required for tolerogenic activity. Likewise, a TTV comprised of GM-CSF and PLP139-151 was a tolerogen in the SJL model of EAE. CONCLUSION: These data indicated that fusion proteins containing GM-CSF coupled to myelin auto-antigens elicit tolerance rather than immunity.
Date:2011
Reference Type:Literature
PubMed ID:22208499
Journal:BMC Immunol
Journal Volume:12
Article Pages:72
Journal ISSN:1471-2172
Article Chemical List:Autoantigens;Glycoproteins;Immunodominant Epitopes;Myelin-Oligodendrocyte Glycoprotein;Peptide Fragments;Recombinant Fusion Proteins;Vaccines, Subunit;myelin oligodendrocyte glycoprotein (34-56);Granulocyte-Macrophage Colony-Stimulating Factor
Article MeSH List:Animals; Autoantigens(administration & dosage; genetics; metabolism); Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental(drug therapy; immunology); Glycoproteins(administration & dosage; genetics; metabolism); Granulocyte-Macrophage Colony-Stimulating Factor(administration & dosage; genetics; metabolism); Humans; Immune Tolerance; Immunodominant Epitopes(metabolism); Mice; Mice, Inbred C57BL; Multiple Sclerosis(drug therapy; immunology); Myelin-Oligodendrocyte Glycoprotein; Nervous System(immunology); Peptide Fragments(administration & dosage; genetics; metabolism); Recombinant Fusion Proteins(genetics; immunology); Vaccines, Subunit(immunology; therapeutic use)
Curation Last Updated:2014-07-16 23:00:59