Epitopes described in "Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells."

Reference
Article Authors:Souheil-Antoine Younes; George Punkosdy; Stephane Caucheteux; Tao Chen; Zvi Grossman; William E Paul
Article Title:Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells.
Reference Detail
Reference ID:1026051
Abstract:Memory phenotype (CD44(bright), CD25(negative)) CD4 spleen and lymph node T cells (MP cells) proliferate rapidly in normal or germ-free donors, with BrdU uptake rates of 6% to 10% per day and Ki-67 positivity of 18% to 35%. The rapid proliferation of MP cells stands in contrast to the much slower proliferation of lymphocytic choriomeningitis virus (LCMV)-specific memory cells that divide at rates ranging from <1% to 2% per day over the period from 15 to 60 days after LCMV infection. Anti-MHC class II antibodies fail to inhibit the in situ proliferation of MP cells, implying a non-T-cell receptor (TCR)-driven proliferation. Such proliferation is partially inhibited by anti-IL-7R antibody. The sequence diversity of TCR CDR3 gene segments is comparable among the proliferating and quiescent MP cells from conventional and germ-free mice, implying that the majority of proliferating MP cells have not recently derived from a small cohort of cells that expand through multiple continuous rounds of cell division. We propose that MP cells constitute a diverse cell population, containing a subpopulation of slowly dividing authentic antigen-primed memory cells and a majority population of rapidly proliferating cells that did not arise from naïve cells through conventional antigen-driven clonal expansion.
Date:2011
Reference Type:Literature
PubMed ID:22022231
Journal:PLoS Biol
Journal Volume:9
Article Pages:e1001171
Journal ISSN:1545-7885
Article Chemical List:Cytokines;Histocompatibility Antigens Class II;Ki-67 Antigen;Mki67 protein, mouse;Receptors, Antigen, T-Cell;Receptors, Interleukin-7;interleukin-7 receptor, alpha chain;Bromodeoxyuridine
Article MeSH List:Animals; Bromodeoxyuridine(metabolism); CD4-Positive T-Lymphocytes(immunology); Cell Proliferation(drug effects); Cytokines(immunology); Germ-Free Life; Histocompatibility Antigens Class II(immunology); Immunologic Memory(immunology); Ki-67 Antigen(biosynthesis); Lymphocytic choriomeningitis virus(immunology); Mice; Receptors, Antigen, T-Cell(immunology); Receptors, Interleukin-7(immunology)
Curation Last Updated:2014-04-06 20:13:01