Epitopes described in "A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin."

Reference
Article Authors:Jens C Krause; Tshidi Tsibane; Terrence M Tumpey; Chelsey J Huffman; Christopher F Basler; James E Crowe Jr
Article Title:A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin.
Reference Detail
Reference ID:1022471
Abstract:The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive antibodies, but epitopes in the globular head typically elicit strain-specific responses because of the hypervariability of this region. We isolated human monoclonal antibody 5J8, which neutralized a broad spectrum of 20th century H1N1 viruses and the 2009 pandemic H1N1 virus. Fine mapping of the interaction unexpectedly revealed a novel epitope between the receptor-binding pocket and the Ca₂ antigenic site on HA. This antibody exposes a new mechanism underlying broad immunity against H1N1 influenza viruses and identifies a conserved epitope that might be incorporated into engineered H1 virus vaccines.
Date:2011
Reference Type:Literature
PubMed ID:21849447
Journal:J Virol
Journal Volume:85
Article Pages:10905-8
Journal ISSN:1098-5514
Article Chemical List:Antibodies, Monoclonal;Antibodies, Neutralizing;Antibodies, Viral;Epitopes;H1N1 virus hemagglutinin;Hemagglutinin Glycoproteins, Influenza Virus
Article MeSH List:Adult; Animals; Antibodies, Monoclonal(immunology; therapeutic use); Antibodies, Neutralizing(immunology; therapeutic use); Antibodies, Viral(immunology; therapeutic use); Body Weight; Cell Line; Cross Reactions; Disease Models, Animal; Epitope Mapping; Epitopes(immunology); Female; Hemagglutinin Glycoproteins, Influenza Virus(immunology); Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Orthomyxoviridae Infections(drug therapy); Rodent Diseases(drug therapy); Sequence Analysis, DNA; Survival Analysis; Treatment Outcome
Curation Last Updated:2014-04-01 21:21:48