|
| Article Authors: | Jens C Krause; Tshidi Tsibane; Terrence M Tumpey; Chelsey J Huffman; Christopher F Basler; James E Crowe Jr |
|---|
| Article Title: | A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin. |
|---|
|
| Reference ID: | 1022471 |
|---|
| Abstract: | The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive antibodies, but epitopes in the globular head typically elicit strain-specific responses because of the hypervariability of this region. We isolated human monoclonal antibody 5J8, which neutralized a broad spectrum of 20th century H1N1 viruses and the 2009 pandemic H1N1 virus. Fine mapping of the interaction unexpectedly revealed a novel epitope between the receptor-binding pocket and the Ca(2) antigenic site on HA. This antibody exposes a new mechanism underlying broad immunity against H1N1 influenza viruses and identifies a conserved epitope that might be incorporated into engineered H1 virus vaccines. |
|---|
| Affiliations: | Vanderbilt Vaccine Center, Vanderbilt University Medical Center, T-2220 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232-2905. james.crowe@vanderbilt.edu. |
|---|
| Date: | 2011 |
|---|
| Reference Type: | Literature |
|---|
| PubMed ID: | 21849447 |
|---|
| Journal: | J Virol |
|---|
| Journal Volume: | 85 |
|---|
| Article Pages: | 10905-8 |
|---|
| Journal ISSN: | 1098-5514 |
|---|
| Curation Last Updated: | 2013-05-28 22:33:05 |
|---|
