Epitopes described in "Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions."

Article Authors:Brian D Rudd; Vanessa Venturi; Gang Li; Partha Samadder; James M Ertelt; Sing Sing Way; Miles P Davenport; Janko Nikolich-┼Żugich
Article Title:Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions.
Reference Detail
Reference ID:1026054
Abstract:Immunity against new infections declines in the last quartile of life, as do numbers of naive T cells. Peripheral maintenance of naive T cells over the lifespan is necessary because their production drastically declines by puberty, a result of thymic involution. We report that this maintenance is not random in advanced aging. As numbers and diversity of naive CD8(+) T cells declined with aging, surviving cells underwent faster rates of homeostatic proliferation, were selected for high T-cell receptor:pMHC avidity, and preferentially acquired "memory-like" phenotype. These high-avidity precursors preferentially responded to infection and exhibited strong antimicrobial function. Thus, T-cell receptor avidity for self-pMHC provides a proofreading mechanism to maintain some of the fittest T cells in the otherwise crumbling naive repertoire, providing a degree of compensation for numerical and diversity defects in old T cells.
Affiliations:Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Reference Type:Literature
PubMed ID:21813761
Journal:Proc Natl Acad Sci U S A
Journal Volume:108
Article Pages:13694-9
Journal ISSN:0027-8424
Article Chemical List:HLA Antigens;Receptors, Antigen, T-Cell
Article MeSH List:Aging(immunology); Animals; CD8-Positive T-Lymphocytes(cytology; immunology); Cell Aging(immunology); Cell Proliferation; HLA Antigens(immunology); Homeostasis(immunology); Immunity(immunology); Immunologic Memory; Lymphocyte Count; Mice; Receptors, Antigen, T-Cell(immunology)
Curation Last Updated:2015-07-30 20:47:56