Epitopes described in "Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease."

Article Authors:Richard Dodel; Karthikeyan Balakrishnan; Kathy Keyvani; Oliver Deuster; Frauke Neff; Luminita-Cornelia Andrei-Selmer; Stephan Röskam; Carsten Stüer; Yousef Al-Abed; Carmen Noelker; Monika Balzer-Geldsetzer; Wolfgang Oertel; Yansheng Du; Michael Bacher
Article Title:Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.
Reference Detail
Reference ID:1021985
Abstract:Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against -amyloid (A) in animal models of AD has been shown to be effective on the molecular level but also on the behavioral level. Recently, we reported naturally occurring autoantibodies against A (NAbs-A) being reduced in Alzheimer's disease patients. Here, we further investigated their physiological role: in epitope mapping studies, NAbs-A recognized the mid-/C-terminal end of A and preferentially bound to oligomers but failed to bind to monomers/fibrils. NAbs-A were able to interfere with A peptide toxicity, but NAbs-A did not readily clear senile plaques although early fleecy-like plaques were reduced. Administration of NAbs-A in transgenic mice improved the object location memory significantly, almost reaching performance levels of wild-type control mice. These findings suggest a novel physiological mechanism involving NAbs-A to dispose of proteins or peptides that are prone to forming toxic aggregates.
Affiliations:Department of Neurology, Philipps University Marburg, D-35043 Marburg, Germany. dodel@med.uni-marburg.de
Reference Type:Literature
PubMed ID:21490226
Journal:J Neurosci
Journal Volume:31
Article Pages:5847-54
Journal ISSN:1529-2401
Article Chemical List:Amyloid beta-Peptides;Autoantibodies;Epitopes;Immunoglobulin G
Article MeSH List:Alzheimer Disease(genetics; immunology; pathology; psychology); Amyloid beta-Peptides(immunology); Animals; Animals, Genetically Modified; Antibody Formation; Autoantibodies(immunology); Behavior, Animal; Brain(pathology); Cells, Cultured; Chromatography, Gel; Disease Models, Animal; Epitopes; Female; Humans; Immunization; Immunoglobulin G(immunology); Immunohistochemistry; Mice; Mice, Inbred C57BL; Models, Molecular; Plaque, Amyloid(pathology); Surface Plasmon Resonance
Curation Last Updated:2016-04-05 22:57:42