Epitopes described in "Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes."

Article Authors:Shalyn C Clute; Yuri N Naumov; Levi B Watkin; Nuray Aslan; John L Sullivan; David A Thorley-Lawson; Katherine Luzuriaga; Raymond M Welsh; Roberto Puzone; Franco Celada; Liisa K Selin
Article Title:Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes.
Reference Detail
Reference ID:1021207
Abstract:Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a process known as heterologous immunity. Because a challenge virus epitope may react with only a subset of the T cell repertoire in a cross-reactive epitope-specific memory pool, the vigorous cross-reactive response may be narrowly focused, or oligoclonal. We show in this article, by examining human T cell cross-reactivity between the HLA-A2-restricted influenza A virus-encoded M1(58-66) epitope (GILGFVFTL) and the dissimilar Epstein-Barr virus-encoded BMLF1(280-288) epitope (GLCTLVAML), that, under some conditions, heterologous immunity can lead to a significant broadening, rather than a narrowing, of the TCR repertoire. We suggest that dissimilar cross-reactive epitopes might generate a broad, rather than a narrow, T cell repertoire if there is a lack of dominant high-affinity clones; this hypothesis is supported by computer simulation.
Affiliations:Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Reference Type:Literature
PubMed ID:21048112
Journal:J Immunol
Journal Volume:185
Article Pages:6753-64
Journal ISSN:0022-1767
Article Chemical List:Epitopes, T-Lymphocyte;HLA-A2 Antigen;Immunodominant Epitopes;M1 protein, Influenza A virus;Oligopeptides;Peptide Fragments;Receptors, Antigen, T-Cell;Viral Matrix Proteins;glycyl-leucyl-cysteinyl-threonyl-leucyl-valyl-alanyl-methionyl-leucine;influenza matrix peptide (58-66)
Article MeSH List:Adolescent; Adult; CD8-Positive T-Lymphocytes(immunology; metabolism; virology); Clone Cells; Cross Reactions; Epitopes, T-Lymphocyte(metabolism); HLA-A2 Antigen(immunology; metabolism); Herpesvirus 4, Human(immunology; metabolism); Humans; Immunodominant Epitopes(metabolism); Influenza A virus(immunology; metabolism); Middle Aged; Oligopeptides(immunology; metabolism); Peptide Fragments(immunology; metabolism); Receptors, Antigen, T-Cell(metabolism); Viral Matrix Proteins(immunology; metabolism); Young Adult
Curation Last Updated:2015-06-05 02:31:35