|
| Article Authors: | Shalyn C Clute; Yuri N Naumov; Levi B Watkin; Nuray Aslan; John L Sullivan; David A Thorley-Lawson; Katherine Luzuriaga; Raymond M Welsh; Roberto Puzone; Franco Celada; Liisa K Selin |
|---|
| Article Title: | Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes. |
|---|
|
| Reference ID: | 1021207 |
|---|
| Abstract: | Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a process known as heterologous immunity. Because a challenge virus epitope may react with only a subset of the T cell repertoire in a cross-reactive epitope-specific memory pool, the vigorous cross-reactive response may be narrowly focused, or oligoclonal. We show in this article, by examining human T cell cross-reactivity between the HLA-A2-restricted influenza A virus-encoded M1(58-66) epitope (GILGFVFTL) and the dissimilar Epstein-Barr virus-encoded BMLF1(280-288) epitope (GLCTLVAML), that, under some conditions, heterologous immunity can lead to a significant broadening, rather than a narrowing, of the TCR repertoire. We suggest that dissimilar cross-reactive epitopes might generate a broad, rather than a narrow, T cell repertoire if there is a lack of dominant high-affinity clones; this hypothesis is supported by computer simulation. |
|---|
| Affiliations: | Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA. |
|---|
| Date: | 2010 |
|---|
| Reference Type: | Literature |
|---|
| PubMed ID: | 21048112 |
|---|
| Journal: | J Immunol |
|---|
| Journal Volume: | 185 |
|---|
| Article Pages: | 6753-64 |
|---|
| Journal ISSN: | 1550-6606 |
|---|
| Article Chemical List: | Epitopes, T-Lymphocyte;HLA-A2 Antigen;Immunodominant Epitopes;M1 protein, Influenza A virus;Oligopeptides;Peptide Fragments;Receptors, Antigen, T-Cell;Viral Matrix Proteins;glycyl-leucyl-cysteinyl-threonyl-leucyl-valyl-alanyl-methionyl-leucine;influenza matrix peptide (58-66) |
|---|
| Article MeSH List: | Adolescent; Adult; CD8-Positive T-Lymphocytes(immunology; metabolism; virology); Clone Cells; Cross Reactions; Epitopes, T-Lymphocyte(metabolism); HLA-A2 Antigen(immunology; metabolism); Herpesvirus 4, Human(immunology; metabolism); Humans; Immunodominant Epitopes(metabolism); Influenza A virus(immunology; metabolism); Middle Aged; Oligopeptides(immunology; metabolism); Peptide Fragments(immunology; metabolism); Receptors, Antigen, T-Cell(metabolism); Viral Matrix Proteins(immunology; metabolism); Young Adult |
|---|
| Curation Last Updated: | 2011-03-07 20:01:26 |
|---|
