Epitopes described in "Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells."

Article Authors:Joel N H Stern; Derin B Keskin; Zenichiro Kato; Hanspeter Waldner; Sonja Schallenberg; Ana Anderson; Harald von Boehmer; Karsten Kretschmer; Jack L Strominger
Article Title:Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.
Reference Detail
Reference ID:1020981
Abstract:In T cell-mediated autoimmune diseases, self-reactive T cells with known antigen specificity appear to be particularly promising targets for antigen-specific induction of tolerance without compromising desired protective host immune responses. Several lines of evidence suggest that delivery of antigens to antigen-presenting dendritic cells (DCs) in the steady state (i.e., to immature DCs) may represent a suitable approach to induce antigen-specific T-cell tolerance peripherally. Here, we report that anti-DEC205-mediated delivery of the self-peptide proteolipid protein (PLP)139-151 to DCs ameliorated clinical symptoms in the PLP-induced SJL model of experimental autoimmune encephalomyelitis. Splenocytes from treated mice were anergized to PLP139-151, and IL-17 secretion was markedly reduced. Moreover, we show directly, using transgenic CD4(+) V6(+) TCR T cells specific for PLP139-151, that, under the conditions of the present experiments, these cells also became anergic. In addition, evidence for a CD4(+) T cell-mediated suppressor mechanism was obtained.
Affiliations:Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. jstern@fas.harvard.edu.
Reference Type:Literature
PubMed ID:20855626
Journal:Proc Natl Acad Sci U S A
Journal Volume:107
Article Pages:17280-5
Journal ISSN:0027-8424
Article Chemical List:Interleukin-17;Myelin Proteolipid Protein;Peptide Fragments;Recombinant Fusion Proteins;myelin proteolipid protein (139-151)
Article MeSH List:Adoptive Transfer; Animals; Cell Line; Dendritic Cells(immunology); Encephalomyelitis, Autoimmune, Experimental(immunology); Female; Humans; Immune Tolerance(immunology); Interleukin-17(immunology); Mice; Mice, Inbred Strains; Mice, Transgenic; Myelin Proteolipid Protein(immunology); Peptide Fragments(immunology); Recombinant Fusion Proteins(genetics; metabolism)
Curation Last Updated:2015-07-30 20:37:48