|
| Article Authors: | Joel N H Stern; Derin B Keskin; Zenichiro Kato; Hanspeter Waldner; Sonja Schallenberg; Ana Anderson; Harald von Boehmer; Karsten Kretschmer; Jack L Strominger |
|---|
| Article Title: | Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. |
|---|
|
| Reference ID: | 1020981 |
|---|
| Abstract: | In T cell-mediated autoimmune diseases, self-reactive T cells with known antigen specificity appear to be particularly promising targets for antigen-specific induction of tolerance without compromising desired protective host immune responses. Several lines of evidence suggest that delivery of antigens to antigen-presenting dendritic cells (DCs) in the steady state (i.e., to immature DCs) may represent a suitable approach to induce antigen-specific T-cell tolerance peripherally. Here, we report that anti-DEC205-mediated delivery of the self-peptide proteolipid protein (PLP)139-151 to DCs ameliorated clinical symptoms in the PLP-induced SJL model of experimental autoimmune encephalomyelitis. Splenocytes from treated mice were anergized to PLP139-151, and IL-17 secretion was markedly reduced. Moreover, we show directly, using transgenic CD4(+) V6(+) TCR T cells specific for PLP139-151, that, under the conditions of the present experiments, these cells also became anergic. In addition, evidence for a CD4(+) T cell-mediated suppressor mechanism was obtained. |
|---|
| Affiliations: | Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. jstern@fas.harvard.edu |
|---|
| Date: | 2010 |
|---|
| Reference Type: | Literature |
|---|
| PubMed ID: | 20855626 |
|---|
| Journal: | Proc Natl Acad Sci U S A |
|---|
| Journal Volume: | 107 |
|---|
| Article Pages: | 17280-5 |
|---|
| Journal ISSN: | 1091-6490 |
|---|
| Article Chemical List: | Interleukin-17;Myelin Proteolipid Protein;Peptide Fragments;Recombinant Fusion Proteins;proteolipid protein 139-151 |
|---|
| Article MeSH List: | Adoptive Transfer; Animals; Cell Line; Dendritic Cells(immunology); Encephalomyelitis, Autoimmune, Experimental(immunology); Female; Humans; Immune Tolerance(immunology); Interleukin-17(immunology); Mice; Mice, Inbred Strains; Mice, Transgenic; Myelin Proteolipid Protein(immunology); Peptide Fragments(immunology); Recombinant Fusion Proteins(genetics; metabolism) |
|---|
| Curation Last Updated: | 2013-06-05 16:04:58 |
|---|
