Epitopes described in "Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection."

Article Authors:Jie Liu; Tracy J Ruckwardt; Man Chen; John D Nicewonger; Teresa R Johnson; Barney S Graham
Article Title:Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection.
Reference Detail
Reference ID:1020906
Abstract:The role of epitope-specific regulatory CD4 T cells in modulating CD8 T-cell-mediated immunopathology during acute viral infection has not been well defined. In the murine model of respiratory syncytial virus (RSV) infection, CD8 T cells play an important role in both viral clearance and immunopathology. We have previously characterized two RSV epitope-specific CD4 T-cell responses with distinct phenotypic properties. One of them, the IA(b)M(209)-specific subset, constitutively expresses FoxP3 and modulates CD8 T-cell function in vitro. We show here that the IA(b)M(209)-specific CD4 T-cell response regulates CD8 T-cell function in vivo and is associated with diminished RSV-induced illness without affecting viral clearance at the site of infection. Achieving the optimal balance of regulatory and effector T-cell function is an important consideration for designing future vaccines.
Affiliations:Vaccine Research Center, NIAID, National Institutes of Health, 40 Convent Dr., Bethesda, MD 20892-3017, USA.
Reference Type:Literature
PubMed ID:20686045
Journal:J Virol
Journal Volume:84
Article Pages:10501-9
Journal ISSN:1098-5514
Article Chemical List:Antigens, Viral;Cytokines;Epitopes, T-Lymphocyte;Forkhead Transcription Factors;Foxp3 protein, mouse;Interleukin-7 Receptor alpha Subunit;Respiratory Syncytial Virus Vaccines;Viral Matrix Proteins
Article MeSH List:Animals; Antigens, Viral(genetics); CD8-Positive T-Lymphocytes(immunology; pathology); Cytokines(biosynthesis); Epitopes, T-Lymphocyte(genetics); Female; Forkhead Transcription Factors(metabolism); Interleukin-7 Receptor alpha Subunit(metabolism); Lymphocyte Depletion; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Respiratory Syncytial Virus Infections(immunology; metabolism; pathology); Respiratory Syncytial Virus Vaccines(immunology); Respiratory Syncytial Viruses(genetics; immunology); T-Lymphocyte Subsets(immunology; metabolism; pathology); T-Lymphocytes, Regulatory(immunology; metabolism; pathology); Viral Matrix Proteins(genetics; immunology)
Curation Last Updated:2015-07-30 20:37:41