Epitopes described in "Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells."

Reference
Article Authors:Marc Vocanson; Aurore Rozieres; Anca Hennino; Gaelle Poyet; Vincent Gaillard; Sarah Renaudineau; Amine Achachi; Josette Benetiere; Dominique Kaiserlian; Bertrand Dubois; Jean-Fran├žois Nicolas
Article Title:Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells.
Reference Detail
Reference ID:1020791
Abstract:BACKGROUND: CD4(+)CD25(+) regulatory T (Treg) cells are involved in the downmodulation of numerous immune responses to pathogens, tumors, or allergens. OBJECTIVE: In this study, we further characterized the nature of Treg cells that control skin inflammatory reactions to haptens. METHODS: In a model of contact hypersensitivity to 2,4-dinitro-fluorobenzene, we have investigated the phenotype, the specificity, and the origin of Treg cells that modulate the priming of effector CD8(+) T cells responsible for the development of the pathology. RESULTS: 2,4-Dinitrofluorobenzene immunization induced a population of CD4(+)CD25(+) Treg cells that controlled CD8(+) T-cell effector responses in a hapten-specific manner in vivo. High levels of inducible costimulator (ICOS) expression defined a population of CD4(+)CD25(+)FoxP3(+) (forkhead box protein 3) Treg cells that presented superior suppressive activity. Importantly, ICOS(+) Treg cells were distinguishable from all other FoxP3(+) Treg cells by the expression of IL-10, IL-17, and IFN-gamma. Hapten-specific Treg cells proliferating in response to their cognate antigen in vivo predominantly displayed a CD25(+)FoxP3(+)ICOS(+) phenotype. By using reporter mice, we showed that ICOS(+) Treg cells derived from the expansion of natural CD4(+)FoxP3(+) Treg cells rather than generation of adaptive Treg cells. Furthermore, the generation of ICOS(+) Treg cells depended on innate cells rather than the effector CD8(+) T-cell population. CONCLUSION: Taken together, our data show that a population of CD4(+)CD25(+)FoxP3(+) T cells upregulates ICOS on in vivo sensitization and specifically suppresses hapten-reactive CD8(+) T cells both in vivo and in vitro.
Date:2010
Reference Type:Literature
PubMed ID:20624644
Journal:J Allergy Clin Immunol
Journal Volume:126
Article Pages:280-9, 289.e1-7
Journal ISSN:0091-6749
Article Chemical List:Antigens, Differentiation, T-Lymphocyte;Cytokines;Forkhead Transcription Factors;Foxp3 protein, mouse;Haptens;Icos protein, mouse;Inducible T-Cell Co-Stimulator Protein;Dinitrofluorobenzene
Article MeSH List:Animals; Antigens, Differentiation, T-Lymphocyte(biosynthesis; immunology); CD8-Positive T-Lymphocytes(immunology; metabolism); Cell Proliferation(drug effects); Cytokines(biosynthesis; immunology); Dermatitis, Allergic Contact(immunology; metabolism); Dinitrofluorobenzene(adverse effects; pharmacology); Disease Models, Animal; Forkhead Transcription Factors(biosynthesis; immunology); Haptens(adverse effects; pharmacology); Immunity, Innate(drug effects; immunology); Inducible T-Cell Co-Stimulator Protein; Mice; T-Lymphocytes, Regulatory(immunology; metabolism); Th1 Cells(immunology; metabolism); Up-Regulation(drug effects; immunology)
Curation Last Updated:2014-12-11 17:19:10