Epitopes described in "Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III."

Reference
Article Authors:Shuliu Zhang; Evgeniy I Bovshik; Rodrigo Maillard; Gregory D Gromowski; David E Volk; Catherine H Schein; Claire Y-H Huang; David G Gorenstein; James C Lee; Alan D T Barrett; David W C Beasley
Article Title:Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III.
Reference Detail
Reference ID:1019782
Abstract:Site-directed mutagenesis of residues in the BC loop (residues 329-333) of the envelope (E) protein domain III in a West Nile virus (WNV) infectious clone and in plasmids encoding recombinant WNV and dengue type 2 virus domain III proteins demonstrated a critical role for residues in this loop in the function and antigenicity of the E protein. This included a strict requirement for the tyrosine at residue 329 of WNV for virus viability and E domain III folding. The absence of an equivalent residue in this region of yellow fever group viruses and most tick-borne flavivirus suggests there is an evolutionary divergence in the molecular mechanisms of domain III folding employed by different flaviviruses.
Date:2010
Reference Type:Literature
PubMed ID:20447672
Journal:Virology
Journal Volume:403
Article Pages:85-91
Journal ISSN:0042-6822
Article Chemical List:Antibodies, Monoclonal;Antibodies, Neutralizing;Antibodies, Viral;Antigens, Viral;Viral Envelope Proteins
Article MeSH List:Amino Acid Sequence; Animals; Antibodies, Monoclonal(immunology; isolation & purification); Antibodies, Neutralizing(immunology; isolation & purification); Antibodies, Viral(immunology; isolation & purification); Antigens, Viral(genetics; immunology; physiology); Cercopithecus aethiops; Female; Humans; Mice; Microbial Viability; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Neutralization Tests; Protein Folding; Protein Structure, Tertiary; Sequence Alignment; Vero Cells; Viral Envelope Proteins(genetics; immunology; physiology); Virus Attachment; West Nile virus(genetics; immunology; physiology)
Curation Last Updated:2014-10-03 22:08:49