Epitopes described in "Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells."

Article Authors:Ryan A Langlois; Kevin L Legge
Article Title:Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.
Reference Detail
Reference ID:1025863
Abstract:Previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza A virus (IAV) infection is mediated via lymph node (LN) dendritic cells (DCs) that express Fas ligand (FasL) and drive FasL-Fas (DC-T)-induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC-mediated elimination of IAV-specific CD8 T cells remain unknown. In this paper, we demonstrate that plasmacytoid DCs (pDCs), which downregulate FasL during sublethal, but not lethal, IAV infection, accumulate to greater numbers within the LNs of lethal dose-infected mice. Further our findings show that pDCs from lethal, but not sublethal, dose IAV infections drive elimination of Fas(+) CD8 T cells and that this elimination occurs only in the absence of TCR recognition of IAV peptide-MHC class I complexes. Together, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose IAV infections by limiting the CD8 T cell response.
Affiliations:Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.
Reference Type:Literature
PubMed ID:20220091
Journal:J Immunol
Journal Volume:184
Article Pages:4440-6
Journal ISSN:0022-1767
Article Chemical List:Antigens, CD8;Antigens, CD95;CD8alpha antigen;Fas Ligand Protein;Fasl protein, mouse
Article MeSH List:Adoptive Transfer; Animals; Antigens, CD8(biosynthesis); Antigens, CD95(biosynthesis; physiology); Apoptosis(immunology); CD8-Positive T-Lymphocytes(immunology; metabolism; pathology); Cell Movement(immunology); Dendritic Cells(immunology; metabolism; transplantation); Down-Regulation(immunology); Fas Ligand Protein(antagonists & inhibitors; biosynthesis; physiology); Immunophenotyping; Influenza A Virus, H1N1 Subtype(immunology); Influenza A Virus, H2N2 Subtype(immunology); Lymph Nodes(immunology; pathology; virology); Lymphocyte Activation(immunology); Lymphocyte Count; Lymphocyte Depletion(methods); Mice; Mice, Inbred BALB C; Mice, Transgenic; Orthomyxoviridae Infections(immunology; mortality; pathology)
Curation Last Updated:2015-07-30 20:47:34