Epitopes described in "IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection."

Article Authors:Jodi McGill; Nico Van Rooijen; Kevin L Legge
Article Title:IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.
Reference Detail
Reference ID:1026040
Abstract:We have recently demonstrated that peripheral CD8 T cells require two separate activation hits to accumulate to high numbers in the lungs after influenza virus infection: a primary interaction with mature, antigen-bearing dendritic cells (DCs) in the lymph node, and a second, previously unrecognized interaction with MHC I-viral antigen-bearing pulmonary DCs in the lungs. We demonstrate that in the absence of lung-resident DC subsets, virus-specific CD8 T cells undergo significantly increased levels of apoptosis in the lungs; however, reconstitution with pulmonary plasmacytoid DCs and CD8alpha(+) DCs promotes increased T cell survival and accumulation in the lungs. Further, our results show that the absence of DCs after influenza virus infection results in significantly reduced levels of IL-15 in the lungs and that pulmonary DC-mediated rescue of virus-specific CD8 T cell responses in the lungs requires trans-presentation of IL-15 via DC-expressed IL-15Ralpha. This study demonstrates a key, novel requirement for DC trans-presented IL-15 in promoting effector CD8 T cell survival in the respiratory tract after virus infection, and suggests that this trans-presentation could be an important target for the development of unique antiviral therapies and more effective vaccine strategies.
Affiliations:Department of Pathology, Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52241, USA.
Reference Type:Literature
PubMed ID:20212069
Journal:J Exp Med
Journal Volume:207
Article Pages:521-34
Journal ISSN:0022-1007
Article Chemical List:Antiviral Agents;Interleukin-15
Article MeSH List:Animals; Antiviral Agents(therapeutic use); CD8-Positive T-Lymphocytes(immunology; pathology; virology); Cell Division; Cell Survival; Dendritic Cells(immunology); Drug Design; Humans; Influenza, Human(immunology); Interleukin-15(metabolism); Lung(immunology; virology); Lymphocyte Activation; Lymphocyte Depletion; Mice; Mice, Inbred BALB C; Models, Animal
Curation Last Updated:2015-07-30 20:47:54