Epitopes described in "Structural basis of respiratory syncytial virus neutralization by motavizumab."

Reference
Article Authors:Jason S McLellan; Man Chen; Albert Kim; Yongping Yang; Barney S Graham; Peter D Kwong
Article Title:Structural basis of respiratory syncytial virus neutralization by motavizumab.
Reference Detail
Reference ID:1018833
Abstract:Motavizumab is approximately tenfold more potent than its predecessor, palivizumab (Synagis), the FDA-approved monoclonal antibody used to prevent respiratory syncytial virus (RSV) infection. The structure of motavizumab in complex with a 24-residue peptide corresponding to its epitope on the RSV fusion (F) glycoprotein reveals the structural basis for this greater potency. Modeling suggests that motavizumab recognizes a different quaternary configuration of the F glycoprotein than that observed in a homologous structure.
Affiliations:Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Date:2010
Reference Type:Literature
PubMed ID:20098425
Journal:Nat Struct Mol Biol
Journal Volume:17
Article Pages:248-50
Journal ISSN:1545-9993
Article Chemical List:gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@52cdf2b6;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@4ef9b532;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@6be70e1f;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@e504c91;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@39d2caee;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@3e08ecea;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@3bfa1677;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@1fd8fd64;gov.nih.nlm.ncbi.www.jaxb.impl.NameOfSubstanceImpl@5ee3c091
Article MeSH List:Antibodies, Monoclonal(chemistry; immunology); Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing(chemistry; immunology); Antibodies, Viral(chemistry; immunology); Antiviral Agents(chemistry; immunology); Crystallography, X-Ray; Epitopes(chemistry; immunology); Humans; Models, Molecular; Neutralization Tests; Protein Structure, Quaternary; Respiratory Syncytial Viruses(immunology); Viral Fusion Proteins(chemistry; immunology)
Curation Last Updated:2015-01-17 22:44:27