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| Article Authors: | Jason S McLellan; Man Chen; Albert Kim; Yongping Yang; Barney S Graham; Peter D Kwong |
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| Article Title: | Structural basis of respiratory syncytial virus neutralization by motavizumab. |
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| Reference ID: | 1018833 |
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| Abstract: | Motavizumab is approximately tenfold more potent than its predecessor, palivizumab (Synagis), the FDA-approved monoclonal antibody used to prevent respiratory syncytial virus (RSV) infection. The structure of motavizumab in complex with a 24-residue peptide corresponding to its epitope on the RSV fusion (F) glycoprotein reveals the structural basis for this greater potency. Modeling suggests that motavizumab recognizes a different quaternary configuration of the F glycoprotein than that observed in a homologous structure. |
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| Affiliations: | Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. |
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| Date: | 2010 |
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| Reference Type: | Literature |
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| PubMed ID: | 20098425 |
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| Journal: | Nat Struct Mol Biol |
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| Journal Volume: | 17 |
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| Article Pages: | 248-50 |
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| Journal ISSN: | 1545-9985 |
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| Article Chemical List: | Antibodies, Monoclonal;Antibodies, Neutralizing;Antibodies, Viral;Antiviral Agents;Epitopes;F protein, human respiratory syncytial virus;Viral Fusion Proteins;motavizumab |
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| Article MeSH List: | Antibodies, Monoclonal(chemistry; immunology); Antibodies, Neutralizing(chemistry; immunology); Antibodies, Viral(chemistry; immunology); Antiviral Agents(chemistry; immunology); Crystallography, X-Ray; Epitopes(chemistry; immunology); Humans; Models, Molecular; Neutralization Tests; Protein Structure, Quaternary; Respiratory Syncytial Viruses(immunology); Viral Fusion Proteins(chemistry; immunology) |
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| Curation Last Updated: | 2012-05-31 20:43:25 |
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