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| Article Authors: | Diego Gomez-Nicola; Alessandra Spagnolo; Carmen Guaza; Manuel Nieto-Sampedro |
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| Article Title: | Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice. |
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| Reference ID: | 1019077 |
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| Abstract: | IL-15 initially identified as a T proliferating cytokine has several structural and biological similarities with IL-2 and has been associated with a number of autoimmune diseases. Because of the scarcity of information available on the role of IL-15 in MS pathogenesis, we have investigated how the absence of IL-15 affected the development of experimental autoimmune encephalomyelitis, a mouse model of MS. Following immunization of IL-15(-/-) and C57BL/6 mice with MOG(35-55), we observed a more severe neurological impairment in the IL-15 knockout mice than in the wild-type group. The enhanced disease severity in IL-15(-/-) mice was associated with greater demyelination in the spinal cord, increased immune cell infiltration and inflammation. These events may be related to the higher CD4/CD8 ratio and the almost absent NK cell activity, congenital immune features of IL-15KO mice. Moreover, we found that the fractalkine receptor CX3CR1 was overexpressed in the spinal cord of IL-15(-/-) mice, mainly localized on infiltrating CD8(+) T cells. How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated. |
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| Affiliations: | Neural Plasticity Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones CientÃficas, 28002 Madrid, Spain. |
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| Date: | 2010 |
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| Reference Type: | Literature |
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| PubMed ID: | 20070942 |
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| Journal: | Exp Neurol |
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| Journal Volume: | 222 |
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| Article Pages: | 235-42 |
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| Journal ISSN: | 1090-2430 |
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| Article Chemical List: | Antigens, CD4;Antigens, CD8;Cx3cr1 protein, mouse;Cytokines;Glycoproteins;Interleukin-15;Myelin Basic Proteins;Peptide Fragments;Receptors, Chemokine;myelin oligodendrocyte glycoprotein (35-55) |
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| Article MeSH List: | Analysis of Variance; Animals; Antigens, CD4(metabolism); Antigens, CD8(metabolism); Cytokines(metabolism); Demyelinating Diseases(etiology; pathology); Eliminative Behavior, Animal; Encephalomyelitis, Autoimmune, Experimental(chemically induced; genetics; pathology; physiopathology); Flow Cytometry; Gene Expression Regulation; Glycoproteins; Interleukin-15(deficiency); Killer Cells, Natural(physiology); Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Basic Proteins(metabolism); Neutrophil Infiltration(immunology); Peptide Fragments; Receptors, Chemokine(metabolism); Spinal Cord(immunology; physiopathology) |
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| Curation Last Updated: | 2013-05-28 22:06:33 |
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