Epitopes described in "Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice."

Article Authors:Diego Gomez-Nicola; Alessandra Spagnolo; Carmen Guaza; Manuel Nieto-Sampedro
Article Title:Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice.
Reference Detail
Reference ID:1019077
Abstract:IL-15 initially identified as a T proliferating cytokine has several structural and biological similarities with IL-2 and has been associated with a number of autoimmune diseases. Because of the scarcity of information available on the role of IL-15 in MS pathogenesis, we have investigated how the absence of IL-15 affected the development of experimental autoimmune encephalomyelitis, a mouse model of MS. Following immunization of IL-15(-/-) and C57BL/6 mice with MOG(35-55), we observed a more severe neurological impairment in the IL-15 knockout mice than in the wild-type group. The enhanced disease severity in IL-15(-/-) mice was associated with greater demyelination in the spinal cord, increased immune cell infiltration and inflammation. These events may be related to the higher CD4/CD8 ratio and the almost absent NK cell activity, congenital immune features of IL-15KO mice. Moreover, we found that the fractalkine receptor CX3CR1 was overexpressed in the spinal cord of IL-15(-/-) mice, mainly localized on infiltrating CD8(+) T cells. How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated.
Affiliations:Neural Plasticity Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Científicas, 28002 Madrid, Spain.
Reference Type:Literature
PubMed ID:20070942
Journal:Exp Neurol
Journal Volume:222
Article Pages:235-42
Journal ISSN:0014-4886
Article Chemical List:Antigens, CD4;Antigens, CD8;Cx3cr1 protein, mouse;Cytokines;Glycoproteins;Interleukin-15;Myelin Basic Protein;Myelin-Oligodendrocyte Glycoprotein;Peptide Fragments;Receptors, Chemokine;myelin oligodendrocyte glycoprotein (35-55)
Article MeSH List:Analysis of Variance; Animals; Antigens, CD4(metabolism); Antigens, CD8(metabolism); Cytokines(metabolism); Demyelinating Diseases(etiology; pathology); Eliminative Behavior, Animal; Encephalomyelitis, Autoimmune, Experimental(chemically induced; genetics; pathology; physiopathology); Flow Cytometry; Gene Expression Regulation; Glycoproteins; Interleukin-15(deficiency); Killer Cells, Natural(physiology); Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Basic Protein(metabolism); Myelin-Oligodendrocyte Glycoprotein; Neutrophil Infiltration(immunology); Peptide Fragments; Receptors, Chemokine(metabolism); Spinal Cord(immunology; physiopathology)
Curation Last Updated:2014-10-03 21:58:04