Epitopes described in "Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses."

Article Authors:Jens C Krause; Terrence M Tumpey; Chelsey J Huffman; Patricia A McGraw; Melissa B Pearce; Tshidi Tsibane; Rong Hai; Christopher F Basler; James E Crowe Jr
Article Title:Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses.
Reference Detail
Reference ID:1020488
Abstract:The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.
Affiliations:Departments of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Reference Type:Literature
PubMed ID:20042511
Journal:J Virol
Journal Volume:84
Article Pages:3127-30
Journal ISSN:1098-5514
Article Chemical List:Antibodies, Monoclonal;Antibodies, Neutralizing;Antigens, Viral;Hemagglutinin Glycoproteins, Influenza Virus
Article MeSH List:Amino Acid Sequence; Animals; Antibodies, Monoclonal(immunology); Antibodies, Neutralizing(immunology); Antigens, Viral(genetics; immunology); Cell Line; Disease Outbreaks; Hemagglutinin Glycoproteins, Influenza Virus(genetics; immunology); Humans; Influenza A Virus, H1N1 Subtype(genetics; immunology); Influenza, Human(epidemiology; immunology); Molecular Sequence Data; Neutralization Tests; Orthomyxoviridae Infections(epidemiology; immunology); Sequence Alignment; Swine
Curation Last Updated:2016-03-22 17:53:27