Epitopes described in "Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease."

Article Authors:Andrea Marcello; Oliver Wirths; Thomas Schneider-Axmann; Malin Degerman-Gunnarsson; Lars Lannfelt; Thomas A Bayer
Article Title:Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease.
Reference Detail
Reference ID:1022208
Abstract:In the present work, we investigated the level of IgM autoantibodies directed against different A epitopes as potential diagnostic biomarker for Alzheimer's disease (AD). Anti-A autoantibody levels were measured in 75 plasma samples from patients with AD, individuals with mild cognitive impairment (MCI), and healthy age- and sex-matched controls (HC). To validate the presence of anti-A IgMs, pooled plasma samples were subjected to gel-filtration analysis. The mean level of pGluA-IgM (N-terminal truncated starting at position three with pyroglutamate) was significantly decreased in AD patients as compared to HC. In the group of MCI patients there was a significant positive correlation between pGluA-IgM and cognitive decline analyzed by MMSE (rho = 0.58, d.f. = 13, p = 0.022). These observations indicate that the level of IgM autoantibodies against pGluA is a promising plasma biomarker for AD and correlates with the cognitive status of individuals at risk to develop AD.
Reference Type:Literature
PubMed ID:19781815
Journal:Neurobiol Aging
Journal Volume:32
Article Pages:1379-87
Journal ISSN:0197-4580
Article Chemical List:Amyloid beta-Peptides;Autoantibodies;Biological Markers;Epitopes;Immunoglobulin M;Peptide Fragments;amyloid beta-protein (1-42);Pyrrolidonecarboxylic Acid
Article MeSH List:Aged; Aged, 80 and over; Alzheimer Disease(blood; diagnosis; immunology); Amyloid beta-Peptides(blood; immunology); Autoantibodies(biosynthesis; blood); Biological Markers(blood); Epitopes(blood; immunology); Female; Humans; Immunoglobulin M(biosynthesis; blood); Male; Peptide Fragments(blood; immunology); Predictive Value of Tests; Pyrrolidonecarboxylic Acid(blood; immunology)
Curation Last Updated:2014-10-03 22:22:04