Epitopes described in "SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo."

Reference
Article Authors:Li-Fei Hou; Shi-Jun He; Jun-Xia Wang; Yang Yang; Feng-Hua Zhu; Yu Zhou; Pei-Lan He; Yu Zhang; Yi-Fu Yang; Ying Li; Wei Tang; Jian-Ping Zuo
Article Title:SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo.
Reference Detail
Reference ID:1027608
Abstract:In the present study, we investigated the immunosuppressive effects and underlying mechanisms of beta-aminoarteether maleate (SM934), a derivative of artemisinin, against T cell activation in vitro and in vivo. In vitro, SM934 significantly inhibited the proliferation of splenocytes induced by concanavalin A (Con A), lipopolysaccharide (LPS), mixed lymphocyte reaction (MLR), and anti-CD3 plus anti-CD28 (anti-CD3/28). SM934 significantly inhibited interferon (IFN)-gamma production and CD4(+) T cell division stimulated by anti-CD3/28. SM934 also promoted apoptosis of CD69(+) population in CD4(+) T cells stimulated by anti-CD3/28. Furthermore, SM934 inhibited interleukin (IL)-2 mediated proliferation and survival through blocking Akt phosphorylation in activated T cells. In ovalbumin (OVA)-immunized mice, oral administration of SM934 suppressed OVA-specific T cell proliferation and IFN-gamma production. SM934 treatment also significantly inhibited the sheep red blood cell (SRBC)-induced delayed type hypersensitivity (DTH) reactions in mice. Taken together, SM934 showed potent immunosuppressive activities in vitro and in vivo. Our results demonstrated that SM934 might be a potential therapeutic agent for immune-related diseases.
Date:2009
Reference Type:Literature
PubMed ID:19772931
Journal:Int Immunopharmacol
Journal Volume:9
Article Pages:1509-17
Journal ISSN:1878-1705
Article Chemical List:Antibodies, Monoclonal;Antigens, CD;Artemisinins;Immunosuppressive Agents;beta-aminoarteether maleate;Interferon-gamma;Ovalbumin;Proto-Oncogene Proteins c-akt
Article MeSH List:Administration, Oral; Animals; Antibodies, Monoclonal; Antigens, CD(biosynthesis; immunology); Apoptosis(drug effects; immunology); Artemisinins(administration & dosage; pharmacology); CD4-Positive T-Lymphocytes(drug effects; immunology; metabolism; pathology); Cell Proliferation(drug effects); Cells, Cultured; Female; Immunization; Immunosuppressive Agents(administration & dosage); Interferon-gamma(secretion); Lymphocyte Activation(drug effects); Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin(immunology); Proto-Oncogene Proteins c-akt(metabolism); T-Cell Antigen Receptor Specificity(immunology)
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