Epitopes described in "Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection."

Reference
Article Authors:Jodi McGill; Kevin L Legge
Article Title:Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection.
Reference Detail
Reference ID:1025914
Abstract:Following influenza virus infection, CD8 T cells encounter mature, Ag-bearing dendritic cells within the draining lymph nodes and undergo activation, programmed proliferation, and differentiation to effector cells before migrating to the lungs to mediate viral clearance. However, it remains unclear whether CD8 T cells continue their proliferation after arriving in the lungs. To address this question, we developed a novel, in vivo, dual-label system using intranasal CFSE and BrdU administration to identify virus-specific CD8 T cells that are actively undergoing cell division while in the lungs. With this technique we demonstrate that a high frequency of virus-specific CD8 T cells incorporate BrdU while in the lungs and that this lung-resident proliferation contributes significantly to the magnitude of the Ag-specific CD8 T cell response following influenza virus infection.
Date:2009
Reference Type:Literature
PubMed ID:19767567
Journal:J Immunol
Journal Volume:183
Article Pages:4177-81
Journal ISSN:0022-1767
Article Chemical List:Epitopes, T-Lymphocyte;Propylene Glycols;fingolimod;Sphingosine
Article MeSH List:Animals; CD8-Positive T-Lymphocytes(immunology; metabolism; virology); Cell Movement(immunology); Cell Proliferation; Epitopes, T-Lymphocyte(immunology); Female; Influenza A Virus, H1N1 Subtype(immunology); Lung(immunology; pathology; virology); Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections(immunology; pathology; virology); Propylene Glycols(pharmacology); Sphingosine(analogs & derivatives; pharmacology)
Curation Last Updated:2014-10-03 22:54:29