Epitopes described in "Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand."

Reference
Article Authors:Sushmita Sinha; Sandhya Subramanian; Lisa Miller; Thomas M Proctor; Chris Roberts; Gregory G Burrows; Arthur A Vandenbark; Halina Offner
Article Title:Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand.
Reference Detail
Reference ID:1014228
Abstract:Recombinant T-cell receptor ligands (RTLs) can reverse clinical and histological signs of experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner, and are currently in clinical trials for treatment of subjects with multiple sclerosis (MS). Antigen specificity of RTL raises the question as to whether this treatment would be successful in MS patients where target antigens are unknown. Using spinal cord homogenate or combinations of two different peptides to induce disease, we found that treatment with single RTL could reverse EAE as long as targeted T-cells were present. Therapy with three different RTLs each caused a significant reduction in IL-17 and increases in IL-10 and IL-13 in peptide-activated splenocytes, reduced proliferation of both cognate and bystander specificities of lymph node cells, and reduced inflammatory lesions and secreted IL-17 and IL-2 from peptide-activated spinal cord cells. These results show that treatment with single RTLs can induce a cytokine switch in cognate T-cells that inhibits both the target and bystander T-cells, providing new evidence for the potential applicability of RTL therapy in MS.
Date:2009
Reference Type:Literature
PubMed ID:19321778
Journal:J Neurosci
Journal Volume:29
Article Pages:3816-23
Journal ISSN:1529-2401
Article Chemical List:Cytokines;Ligands;Peptides;RTL401 fusion protein;Receptors, Antigen, T-Cell;Recombinant Fusion Proteins;Tissue Extracts
Article MeSH List:Animals; Bystander Effect; Cytokines(metabolism); Encephalomyelitis, Autoimmune, Experimental(drug therapy; immunology; metabolism); Female; Ligands; Mice; Peptides(immunology); Receptors, Antigen, T-Cell(immunology; metabolism); Recombinant Fusion Proteins(genetics; immunology; therapeutic use); Spinal Cord(immunology; pathology); T-Cell Antigen Receptor Specificity; T-Lymphocytes(drug effects; immunology; pathology); Tissue Extracts(immunology)
Curation Last Updated:2014-07-16 22:03:22