Epitopes described in "CD8 T cells utilize TRAIL to control influenza virus infection."

Article Authors:Erik L Brincks; Arna Katewa; Tamara A Kucaba; Thomas S Griffith; Kevin L Legge
Article Title:CD8 T cells utilize TRAIL to control influenza virus infection.
Reference Detail
Reference ID:1026028
Abstract:Elimination of influenza virus-infected cells during primary influenza virus infections is thought to be mediated by CD8(+) T cells though perforin- and FasL-mediated mechanisms. However, recent studies suggest that CD8(+) T cells can also utilize TRAIL to kill virally infected cells. Therefore, we herein examined the importance of TRAIL to influenza-specific CD8(+) T cell immunity and to the control of influenza virus infections. Our results show that TRAIL deficiency increases influenza-associated morbidity and influenza virus titers, and that these changes in disease severity are coupled to decreased influenza-specific CD8(+) T cell cytotoxicity in TRAIL(-/-) mice, a decrease that occurs despite equivalent numbers of pulmonary influenza-specific CD8(+) T cells. Furthermore, TRAIL expression occurs selectively on influenza-specific CD8(+) T cells, and high TRAIL receptor (DR5) expression occurs selectively on influenza virus-infected pulmonary epithelial cells. Finally, we show that adoptive transfer of TRAIL(+/+) but not TRAIL(-/-) CD8(+) effector T cells alters the mortality associated with lethal dose influenza virus infections. Collectively, our results suggest that TRAIL is an important component of immunity to influenza infections and that TRAIL deficiency decreases CD8(+) T cell-mediated cytotoxicity, leading to more severe influenza infections.
Affiliations:Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
Reference Type:Literature
PubMed ID:18802095
Journal:J Immunol
Journal Volume:181
Article Pages:4918-25
Journal ISSN:0022-1767
Article Chemical List:TNF-Related Apoptosis-Inducing Ligand;Tnfsf10 protein, mouse
Article MeSH List:Animals; Apoptosis(genetics; immunology); CD8-Positive T-Lymphocytes(cytology; immunology; virology); Cell Line; Influenza A Virus, H1N1 Subtype(growth & development; immunology); Lung(immunology; pathology; virology); Mice; Mice, Inbred C57BL; Mice, Knockout; Orthomyxoviridae Infections(mortality; pathology; prevention & control; virology); TNF-Related Apoptosis-Inducing Ligand(biosynthesis; deficiency; genetics; physiology); Viral Load; Weight Loss(genetics; immunology)
Article Comments:ErratumIn(J Immunol. 2008 Nov 15;181(10)7428 )
Curation Last Updated:2015-07-30 20:47:52