Epitopes described in "Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients."

Article Authors:Masanori Terajima; John Cruz; Anita M Leporati; Laura Orphin; Jenny Aurielle B Babon; Mary Dawn T Co; Pamela Pazoles; Julie Jameson; Francis A Ennis
Article Title:Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients.
Reference Detail
Reference ID:1013468
Abstract:Among 17 HLA-A2-positive healthy adults, CD8+ T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8+ T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8+ T-cell responses in some vaccinees.
Affiliations:Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. masanori.terajima@umassmed.edu.
Reference Type:Literature
PubMed ID:18614638
Journal:J Virol
Journal Volume:82
Article Pages:9283-7
Journal ISSN:1098-5514
Article Chemical List:Epitopes, T-Lymphocyte;HLA-A2 Antigen;Influenza Vaccines;Vaccines, Inactivated;Viral Matrix Proteins
Article MeSH List:CD4-Positive T-Lymphocytes(immunology); CD8-Positive T-Lymphocytes(immunology); Cell Line; Epitopes, T-Lymphocyte(immunology); HLA-A2 Antigen(metabolism); Humans; Influenza A Virus, H1N1 Subtype(immunology); Influenza A Virus, H3N2 Subtype(immunology); Influenza Vaccines(administration & dosage; immunology); Influenza, Human(immunology; prevention & control); Vaccines, Inactivated(administration & dosage; immunology); Viral Matrix Proteins(immunology)
Curation Last Updated:2015-06-05 01:25:48